Although survival rates have improved, over one half of patients with systemic lupus erythematosus have permanent damage in one or more organ systems. Arthritis and cutaneous manifestations are most common, but renal, hematologic and neurologic manifestations contribute largely to morbidity and mortality. Is hydroxychloroquine an immune modulator Lyme disease clarithromycin and hydroxychloroquine Chloroquine exoerythrocytic Plaquenil baseline eye exam duration In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis. Chloroquine Aralen Quinacrine Atabrine. Anti-malarials are particularly useful in treating discoid lupus, subacute cutaneous lupus, and mouth sores associated with lupus; they are also effective in treating rheumatoid arthritis and Sjogren’s syndrome. All information contained within the Johns Hopkins Lupus Center website is. Since the initial success of the treatment of lupus erythematosus with quinacrine Atabrine by Prokoptchouk1a and Popoff and Kutinscheff1b and later by Page,2 in Europe, attempts have been made to find other less toxic antimalarial agents. Numerous investigators3 in this country also have had good. Systemic lupus erythematosus has fascinated physicians for almost a century and remains the prototypic autoimmune disease. Treatment approaches emphasize using a combination of drugs to minimize chronic exposure to corticosteroids. Chloroquine for discoid lupus Hydroxychloroquine Oral Route Description and Brand., Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Plaquenil brand name covered by insurance aetna Hydroxychloroquine and chloroquine phosphate have shown beneficial effects in treating discoid lupus erythematosus DLE. Additionally, The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. Alternative therapies, anecdotal reports, and small, open-label trials as reported by. Discoid Lupus Erythematosus Medication Antimalarial.. CHLOROQUINE DIPHOSPHATE IN TREATMENT OF DISCOID LUPUS.. Treatment of Cutaneous Lupus Erythematosus. It is well known that isolated lesions of chronic discoid lupus erythematosus may be treated by various local applications, e.g. various acids, solid carbon dioxide, and the intralesional injection of gold compounds. 2,3 Recently, we became interested in the report of Ottolenghi-Lodigiani, 4 on the combined intralesional and oral. Hydroxychloroquine Plaquenil Chloroquine Aralen Quinacrine Atabrine What are anti-malarial drugs, and why are they used to treat lupus? Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus CCLE, an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears.