Hydroxychloroquine-induced pigmentation

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  1. Levas User

    Hydroxychloroquine-induced pigmentation


    In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent.

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    The few reports of bluish pigmentation with HCQ described resolution within a few months or did not specifiy the duration of pigmentation after discontinuation of the drug 4, 5, 6. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ.

    Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended.

    Hydroxychloroquine-induced pigmentation

    Drug-associated hyperpigmentation of the oral mucosa report of four., Hydroxychloroquine-Induced Retinal Toxicity - American Academy of.

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  3. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor.

    • Hydroxychloroquine-induced Hyperpigmentation of the Skin..
    • Hydroxychloroquine-Induced Pigmentation in Patients With..
    • Hydroxychloroquine-induced pigmentation in two patients with..

    Blue–grey pigmentation of the skin affects up to 25% of patients taking hydroxychloroquine, especially where there has been bruising. Transverse pigmented nail bands and mucosal pigmentation have also been reported. Rashes may occur in up to 10% of patients, most commonly morbilliform or psoriasiform. IMPORTANCE Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful.

     
  4. Ingate Well-Known Member

    The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. Pregnancy category - Wikipedia PLAQUENIL® - Food and Drug Administration Antimalarial drugs and pregnancy safety, pharmacokinetics.
     
  5. IT Online Well-Known Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Can plaquenil mess up menstrual cycle - Doctor answers on. Hydroxychloroquine Sulfate Menstruation Irregular Reports - DrugInformer Effects of Prednisone and Menstrual Cycle
     
  6. km72 XenForo Moderator

    Will you have Rashes with Plaquenil - eHealthMe Plaquenil and Rashes - from FDA reports Summary Rashes is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have Pain.

    Hydroxychloroquine Side Effects Common, Severe, Long Term.
     
  7. nialor New Member

    Pneumococcal Vaccination For Providers CDC Links with this icon indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention CDC cannot attest to the accuracy of a non-federal website. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website.

    ICD-10-CM Diagnosis Code Z79.899 Other long term.