The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Chloroquine drug info Hydroxychloroquine and smoking Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. All blood work came back "normal", lupus is in remission/ inactive. Yay! Dr stopped Hydroxychloroquine plaquenil yesterday fearing it is now doing more harm than good. Over all I do feel it may have caused increased anxiety and depression and irritability.however lupus alone can trigger those symptoms I'm sure. Apr 28, 2009 And, as far as Plaquenil and eye problems, the Ophthamologists I've talked to including a Neuro Ophthalmologist say that while Plaquenil can cause serious damage to the optic nerve, it's very rare. Annual appointments with an ophthalmologist are important in order to catch any problems early. Medications that are strongly associated with leg cramps include intravenous iron sucrose, conjugated estrogens, raloxifene, naproxen, and teriparatide. Nocturnal leg cramps are associated with vascular disease, lumbar canal stenosis, cirrhosis, hemodialysis, pregnancy, and other medical conditions. Plaquenil leg cramps Low platelet count thrombocytopenia Causes, treatment, and., PLAQUENIL Side Effects, Reviews by Patients - Plaquenil weight gain forumPlaquenil screening doctorHow to wean off plaquenilLow dose naltrexone and plaquenil Jun 25, 2013 hydroxychloroquine is the generic form of Plaquenil but the side effects are the same. My thigh muscles are so sore I can hardly walk, sit or stand. Stairs are a TRUE challenge. I have to struggle up and down taking only one step at a time using only one leg at a time. Hydroxychloroquine - thigh muscle weakness?. Plaquenil and muscle aches and pains?. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Oct 24, 2013 After just 4 days on Plaquenil, I had severe stomach cramps, no appetite, GERD pain, diarrhea and a migraine. Not sure that the migraine was related but it happened on day 4. After contacting my Rheumatologist, I was told to stop taking the drug. QUOTE=DawnI have been on plaquenil for around 8 months or so but these leg cramps have just gotten worse and the ladies I work with told me to get calcium with magnesium. That would help out with the leg cramps but I am worried with all the meds that I take I am afraid that it might interact with the meds. Jul 18, 2008 I have been on 400 mg daily of Plaquenil, last week my doctor took me off of it ue to increase in the pain I had been having in lower back and unbelievable pain in my left leg and especially the extreme pain in the heel of my left foot. It was becoming painful to walk. After 5 days of stopping pain was 80% better.