Chloroquine dose in neonates

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  1. Zodchy Moderator

    Chloroquine dose in neonates


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    Neonatal Deaths Associated With Use Of Benzyl Alcohol -- United States. Sixteen neonatal deaths thought to be caused by the benzyl alcohol preservative used in some intravascular solutions have been reported to the Food and Drug Administration FDA by 2 medical centers 1,2. This represents a total dose of 2.5 g chloroquine phosphate or 1.5 g base in three days. Infants and Children In infants and children, the recommended dose is 10 mg base/kg followed by 5 mg based/kg at 6, 24 and 36 hours total dose 25 mg based/kg. The pediatric dose should never exceed the adult dose regardless of weight. Each 500 mg tablet of Chloroquine phosphate contains the equivalent of 300 mg Chloroquine base. In infants and children the dosage is preferably calculated by body weight. Adult Dose The dosage for prophylaxis is 500 mg = 300 mg base administered once per week on exactly the same day of each week.

    Very small amounts of chloroquine are excreted in breast milk; when given once weekly, the amount of drug is not sufficient to harm the infant nor is the quantity sufficient to protect the child from malaria. The usual dosage for malaria prevention in adults is 500 mg once a week.

    Chloroquine dose in neonates

    Chloroquine Dosage - Malaria Home Page, DailyMed - CHLOROQUINE PHOSPHATE tablet

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  7. If you are also taking kaolin or antacids, take them at least 4 hours before or after using chloroquine. If you are also taking ampicillin, take it at least 2 hours before or after using this medicine. Dosing. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

    • Chloroquine Oral Route Proper Use - Mayo Clinic.
    • Chloroquine - FDA prescribing information, side effects..
    • Chloroquine - Drugs and Lactation Database LactMed..

    Take chloroquine at least 2 hours before or after taking ampicillin. Chloroquine may decrease the amount of ampicillin in your body and the ampicillin may not work as well. The excretion of chloroquine and the major metabolite, desethylchloroquine, in breast milk was investigated in 11 lactating mothers following a single oral dose of chloroquine 600 mg basemaximum daily dose of the drug that the infant received from breast-feeding was about 0.7% of the maternal start dose of the drug in malaria chemotherapy. Survival rates declined in a dose-dependent manner, with 88% survival when treated with 5 mg/kg chloroquine and 13% survival when treated with 1 mg/kg chloroquine. Our results show that chloroquine can be highly effective against HCoV-OC43 infection in newborn mice and may be considered as a future drug against HCoVs.

     
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