Chloroquine for lung cancer

Discussion in 'Canada Drugs Online' started by wwwrucom, 22-Feb-2020.

  1. ganushak New Member

    Chloroquine for lung cancer


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Cures Within Reach funded lab research that suggested that chloroquine could improve the effectiveness of the cancer medication Tarceva erlotinib. The combination is now being studied in a phase II clinical trial at Massachusetts General Hospital in patients with stage IIIB and IV non–small cell lung cancer. Chloroquines are expected to have diverse effects on cancer progression. Inhibition of late autophagy can affect cell survival, as well as antigen processing and presentation in the immune system. Co. It is only last couple of years that chloroquine got sudden attention especially among biologists when cancer biologists noticed its role as an inhibitor of autophagy. Autophagy from Greek auto-oneself, phagy-to eat is a process of self-cannibalization which is dependent on the presence of autophagosomes, autolysosomes, as well as an intact.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Chloroquine for lung cancer

    Chloroquine and hydroxychloroquine for cancer therapy, Dissecting pharmacological effects of chloroquine in cancer.

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  5. Cancer is a disease in which cells in the body grow out of control. When cancer starts in the lungs, it is called lung cancer. Lung cancer begins in the lungs and may spread to lymph nodes or other organs in the body, such as the brain. Cancer from other organs also may spread to the lungs.

    • What Is Lung Cancer? CDC.
    • Chloroquine and Cancer Treatment - Biomedical Research, A..
    • Where and How Chloroquine Fights Cancer Science Signaling.

    The anti-authophagy drug chloroquine may be a unique way to resensitize some cancer patients to treatment. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells. Lung cancer. The combination of HCQ with erlotinib can be used safely in daily doses of 150 mg erlotinib and 1000 mg HCQ, as determined by a phase-1 study in 27 patients with advanced non-small cell lung cancer NSCLC. Of the 19 patients who remained in the study, one had a partial response and four had stable disease as best response.

     
  6. helenwell Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine - Wikipedia Plaquenil Dosage Guide - Plaquenil Use in Autoimmune Diseases
     
  7. kvimo Guest

    Plaquenil Toxicity - Bulls Eye Maculopathy - Retina Gallery ~ Full. Plaquenil Toxicity - Bulls Eye Maculopathy 575 views 70-year-old woman with systemic Lupus erythematosus and clotting problems. She was on the Plaquenil for about eight years and then off the Plaquenil for the last eight years because she developed macular toxicity. Although her vision was hazy, it was stable.

    Retinal Physician - Hydroxychloroquine Maculopathy An Update on.