Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Primary care prescribe plaquenil Plaquenil for sjogren's syndrome If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Learn about the wide-ranging effects of hydroxychloroquine Plaquenil® in the treatment of lupus dosing, benefits, side effects and rare complications of this commonly prescribed medication. Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil pigmentation treatment Hydroxychloroquine MedlinePlus Drug Information, Drug spotlight on hydroxychloroquine Lupus Foundation of. Plaquenil for granuloma annularePreferred practice patterns plaquenilTrade name chloroquine Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Ask the Expert Plaquenil and Sjögren’s. Treatment of hydroxychloroquine-induced hyperpigmentation.. Plaquenil Uses, Dosage & Side Effects -. Treatment with HCQ was discontinued definitively because of skin pigmentation in 2 patients who reported a gradual incomplete fading of hyperpigmentation. Among patients who continued HCQ treatment n = 22, an improvement in pigmented lesions was reported in 6, despite the maintenance of a similar daily dose of HCQ. Hydroxychloroquine Plaquenil is not a new therapy. It has been used in rheumatology for decades and it's proven a very useful medication. There is currently no consensus about treatment for lichen planus pigmentosus LPP. Management includes avoiding things that make it worse in each case, such as sun exposure or friction in body folds via weight loss or wearing loose clothing.