Chloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion

Discussion in 'Canada Drugs' started by Konstantin Velikiy, 16-Mar-2020.

  1. devjatka User

    Chloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion


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    Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial and anticancer activities. 1,2,3 Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 ┬ÁM. 1 It is active against the chloroquine-sensitive GC03 strain of P. falciparum IC 50 = 29.2 nM but has decreased activity against mutant pfcrt P. falciparum IC 50 s. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion Article PDF Available in Autophagy 148 June 2018 with 379 Reads How we measure 'reads'

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    Chloroquine inhibits autophagic flux by decreasing autophagosome lysosome fusion

    Autophagy in cancer moving from understanding mechanism to., Chloroquine for research Cell-culture tested InvivoGen

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  5. Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint. Autophagy Vol. 12, No. 9, pp. 1593-1613.

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    I am trying to see if fusion of the autophagosome and lysosome are prevented in my knocked down cells using bafilomycin, which is a fusion blocker. LC3-II level is decreasing and 2 hr. Inhibition of lysosome degradation on autophagosome formation and responses to GMI. Autophagic cell death is considered a self-destructive process that results from large amounts of autophagic flux. ATP6V0A1 silencing decreased autophagosome and lysosome fusion in GMI-treated CaLu-1/GFP-LC3 lung cancer cells. Dear Wonyul, The observation you are seeing is a reflection of the fact that Chloroquine induces the autophagic aqnd apoptosis process but then inhibits the fusion of the lysosomes with the.

     
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  7. Tahoma User

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). Exam 2 Clinical Pearls-final - Exam 2 Clinical Pearls. Clinical Trials Using Hydroxychloroquine - National Cancer. Clinical Pearls Cases in Rheumatology
     
  8. Baibek Guest

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration.

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  9. alneo Moderator

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives.

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