All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved. Routine vision cover plaquenil Plaquenil eye damage Druginformer Identified Side Effects Neuropathy peripheral, Muscle atrophy, Muscle twitching. Posted By Anonymous in on August 26, 2005 @ am “ Side Effects Twitching, muscle loss, peripheral neuropathy symptoms. My rheumatologist said that he hasn't ever seen a worse reaction to this drug. Muscle biopsy consistently reveals curvilinear bodies and muscle fiber atrophy with vacuolar changes. Most cases manifest as insidious onset proximal myopathy that may be associated with peripheral neuropathy and cardiac myotoxicity. Resolution of symptoms is slow after discontinuation of therapy and may be incomplete. Peripheral neuropathy is found among people who take Plaquenil, especially for people who are female, 60+ old also take medication Methotrexate, and have High blood pressure. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated. Has anyone had neurological issues resolved with a Plaquenil treatment? I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. Years later I am now having small fiber issues in my hands which I think were triggered by side effect of statins and am looking for solutions. Hydroxychloroquine causing neuropathy Drug‐induced peripheral neuropathy in a patient with psoriatic arthritis, Hydroxychloroquine neuromyotoxicity. Is hydroxychloroquine safe during pregnancyPlaquenil malaria treatmentHydroxychloroquine plaquenil and surgeryPrednisone and hydroxychloroquine interaction Jun 25, 2013 I took Plaquenil for Sjogren's Syndrome. It got so I couldn't walk up a curb without help before I switched to oral Methotrexate. My peripheral neuropathy actually went away too, and my rheumy thinks it was a rare, toxic side-effect of the Plaquenil. Hydroxychloroquine - thigh muscle weakness?. Will you have Peripheral neuropathy with Plaquenil - eHealthMe. Hydroxychloroquine Indications, Side Effects, Warnings.. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg administration. Inactive Ingredients Dibasic calcium phosphate USP, hypromellose USP, magnesium stearate NF, polyethylene glycol 400 NF, polysorbate 80 NF, corn starch, titanium dioxide USP, Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARDregulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. I used Plaquenil years ago for extreme muscle and joint issues and it seemed to work fine. All my issues were resolved over a years time on low doses. I believe my problems started with side effects of a statin, which I stopped taking during my Plaquenil treatment but resumed after symptoms were resolved.