Chloroquine treatment in pregnancy

Discussion in 'Canada Pharmacy' started by Heinacrictema, 25-Feb-2020.

  1. dimas666 User

    Chloroquine treatment in pregnancy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine may be used throughout pregnancy for the prophylaxis and treatment of malaria. If chloroquine resistance of the parasite is likely or has been demonstrated, other drugs must be used. Nov 25, 2019 Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine treatment in pregnancy

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  2. Hydroxychloroquine in pregnancy
  3. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue deposition and increased risk of retinal toxicity and of fetal abnormalities 10 - 11.

    • Treatment of SLE in pregnancy and use of Chloroquine The BMJ.
    • Chloroquine - FDA prescribing information, side effects..
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    Chloroquine appears to be more retinotoxic than hydroxychloroquine. Screening recommendations for chloroquine All patients planning to be on long-term treatment should receive a baseline examination including fundus photography and spectral domain optical coherence tomography within 6-12 months of treatment initiation; For pregnant women diagnosed with uncomplicated malaria caused by P. malariae, P. vivax, P. ovale, or chloroquine-sensitive P. falciparum infection, prompt treatment with chloroquine treatment schedule as with non-pregnant adult patients is recommended. Alternatively, hydroxychloroquine, may be given instead. Geriatric. Although appropriate studies on the relationship of age to the effects of chloroquine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of chloroquine in the elderly. However, elderly patients are more likely to have age-related kidney problems.

     
  4. eguar User

    1250 mg orally as a single dose Use: For treatment of mild to moderate acute malaria due to mefloquine-susceptible strains of Plasmodium falciparum (both chloroquine-susceptible and -resistant strains) or P vivax US CDC Recommendations: 750 mg orally as initial dose, followed by 500 mg orally 6 to 12 hours after initial dose Comments: -Recommended for treatment of uncomplicated malaria due to chloroquine-resistant (or unknown resistance) P falciparum (or species not identified) if other preferred regimens cannot be used; not recommended if infection was acquired in Southeast Asia (due to resistance) -With (primaquine or tafenoquine [Krintafel]), recommended for treatment of uncomplicated malaria due to chloroquine-resistant P vivax; this drug should be used alone during pregnancy. Aralen chloroquine Malaria Drug Side Effects & Dosage Recommendations for the Prevention of Malaria Among Travelers CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG
     
  5. Rabik Guest

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