Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Autophagy inhibitors chloroquine How does hydroxychloroquine cause retinopathy Hydroxychloroquine dosage for sjogren's syndrome Chloroquine may be used throughout pregnancy for the prophylaxis and treatment of malaria. If chloroquine resistance of the parasite is likely or has been demonstrated, other drugs must be used. Nov 25, 2019 Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Usage of Chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine treatment in pregnancy Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs, Chloroquine Use During Pregnancy Hydroxychloroquine in pregnancy Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue deposition and increased risk of retinal toxicity and of fetal abnormalities 10 - 11. Treatment of SLE in pregnancy and use of Chloroquine The BMJ. Chloroquine - FDA prescribing information, side effects.. Azithromycin-chloroquine and the intermittent preventive.. Chloroquine appears to be more retinotoxic than hydroxychloroquine. Screening recommendations for chloroquine All patients planning to be on long-term treatment should receive a baseline examination including fundus photography and spectral domain optical coherence tomography within 6-12 months of treatment initiation; For pregnant women diagnosed with uncomplicated malaria caused by P. malariae, P. vivax, P. ovale, or chloroquine-sensitive P. falciparum infection, prompt treatment with chloroquine treatment schedule as with non-pregnant adult patients is recommended. Alternatively, hydroxychloroquine, may be given instead. Geriatric. Although appropriate studies on the relationship of age to the effects of chloroquine have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of chloroquine in the elderly. However, elderly patients are more likely to have age-related kidney problems.