Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Medication similar to plaquenil Hydroxychloroquine loss of appetite Hydroxychloroquine hypokalemia Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Other side effects people have besides Dry eyes * Rashes redness 164 people, 44.69% Joint Pain 163 people, 44.41% Fatigue feeling of tiredness 157 people, 42.78% Pain 145 people, 39.51% Drug Ineffective 137 people, 37.33% * Approximation only. Some reports may have incomplete information. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine side effects dry eyes Common and Rare Side Effects for Plaquenil Oral, Hydroxychloroquine Oral Route Precautions - Mayo Clinic Chloroquine chikungunyaPlaquenil primary biliary cirrhosisChloroquine sulphate arthritisMagnesium with hydroxychloroquin Uncontrolled eye movements unsteadiness, trembling, or other problems with muscle control or coordination vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Will you have Dry eyes with Plaquenil - eHealthMe. Plaquenil. Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Feb 19, 2020 Common side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss.