One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil and being in the sun Stopping plaquenil for surgery American Academy of Ophthalmology AAO 2016 guidelines recommend to use HCQ at dosages ≤5 mg/kg real body weight to minimize toxicity 1. Important risk factors for retinal toxicity are daily and cumulative Summary of dosing guidelines. The new recommended daily dose of HCQ is less than 5 mg/kg of real weight, which has been shown to correlate better with risk than ideal weight. There is no similar demographic data for CQ, but older literature suggests less than 2.3 mg/kg real weight. Mar 08, 2017 The ACR 2016 statement goes on to note that other authors have recommended a dosage of 6.5 mg/kg of actual body weight but capped at 400 mg/day and adjusted for renal insufficiency, and the ACR statement stops short of specifying which dosage strategy it recommends. “The AAO recommendations are much more definitive and state more specifically what screening is recommended and what is a safe dosage,” commented Dr. Rosenbaum. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Aao plaquenil dosing The 2016 American Academy of Ophthalmology Hydroxychloroquine., Revised guidance for patients exposed to chloroquine. Splitting plaquenil tablets Plaquenil Hydroxychloroquine sulfate is a drug originally used to prevent or treat malaria. Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. This type of disease occurs when the body's immune system attacks its own healthy tissue. What Is Plaquenil? - American Academy of Ophthalmology. Hydroxychloroquine dosage recommendations often ignored.. The 2018 ACR Great Debate Hydroxychloroquine Dosing for SLE. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. The longer you use the medication, the higher the risk of toxicity. Nov 10, 2019 American Academy of Ophthalmology AAO 2016 guidelines recommend to use HCQ at dosages ≤5 mg/kg real body weight to minimize toxicity. Important risk factors for retinal toxicity are daily and cumulative dosage of HCQ, duration of treatment, patient age and concomitant renal or liver diseases. Jan 03, 2020 Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial dosage.