Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Plaquenil hyperpigmentation Can chloroquine abort pregnancy Chloroquine and desethyl-chloroquine concentrations in the range of 10 nmol/l UV-detection and of 0.5 nmol/l fluorescence detection could be accurately measured with a relative standard deviation of 12%. The method should be adequate for therapeutic and pharmacokinetic studies. The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. Desethyl Hydroxy Chloroquine CAS 4298-15-1 Desethyl Hydroxy Chloroquine is a metabolite of Hydroxychloroquine. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. Dose adjustment is therefore only required in patients with severe renal impairment. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Desethyl chloroquine Chloroquine - Wikipedia, CAS 4298-14-0 Didesethyl Chloroquine - BOC Sciences Chloroquine mechanism of action lupusPlaquenil kidneysPlaquenil 200mg scleroderma Chloroquine and desethylchloroquine concentrations in blood cells and plasma from Indian patients infected with sensitive or resistant Plasmodium falciparum Chloroquine and desethylchloroquine concentrations in blood.. Hydroxychloroquine DermNet NZ. Product Page. Bisdesethylchloroquine C14H18ClN3 CID 122672 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Jan 14, 1983 The concentration of chloroquine was about two times higher in serum than in plasma and for desethyl-chloroquine the concentration was about four times higher in serum than in plasma. These differences may be explained by a release of chloroquine and desethyl-chloroquine from thrombocytes during the coagulation of blood. This study presents a liquid chromatography tandem mass spectrometry LC-MS/MS method for the simultaneous determination of chloroquine CQ and its metabolite desethyl chloroquine DCQ in human.