Plasmodium falciparum chloroquine resistance first seen

Discussion in 'Canadian Drugs' started by Alex-76, 20-Mar-2020.

  1. miasik Well-Known Member

    Plasmodium falciparum chloroquine resistance first seen


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    History of Plasmodium falciparum drug resistanceAntimalarial drug resistance first emerged in Southeast Asia and has subsequently spread to Africa through the Indian subcontinent 1. Chloroquine CQ resistance emerged simultaneously and independently in South America and Southeast Asia 2. The resistant strains of the parasites arrived at the East African coasts from Southeast Asia in the. Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the `digestive vacuole' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might underlie the decreased accumulation of chloroquine by chloroquine-resistant. And that’s what is so exciting about the image above. It presents the unprecedented, 3D atomic-resolution structure of a protein made by P. falciparum that’s been a major source of its resistance the chloroquine-resistance transporter protein, or PfCRT. In this cropped density map, you see part of the protein’s biochemical structure.

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    Plasmodium falciparum chloroquine resistance first seen

    Chloroquine Resistance in Plasmodium falciparum - microbewiki, The pH of the digestive vacuole of Plasmodium falciparum.

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  3. Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

    • Drug Resistance in the Malaria-Endemic World - CDC.
    • Plasmodium falciparum – NIH Director's Blog.
    • CRT - Chloroquine resistance transporter - Plasmodium falciparum - CRT..

    Despite its strategic location and importance, malaria epidemiology and molecular status of chloroquine resistance had not been well documented, and since chloroquine CQ, as the first-line treatment in Plasmodium falciparum infection was discontinued since 2008, it was expected that CQ-sensitive haplotype would be more abundant. We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine as the first-line drug for malaria in Haiti. Artemisinin-based therapy can be used as alternative therapy. These results demonstrate the alarming observation of Plasmodium falciparum strains resistant in-vitro to chloroquine in a region where in vivo resistance has not been observed hitherto. View Show.

     
  4. barney Well-Known Member

    Malaria is an infection caused by single-celled parasites that enter the blood through the bite of an Anopheles mosquito. Malaria - Diagnosis and treatment - Mayo Clinic Mefloquine Dosage Guide with Precautions - Quinine, an old anti-malarial drug in a modern world role in.
     
  5. vin10 New Member

    Chloroquine Dosage - Malaria Home Page The standard chloroquine dose for treating malaria in adults is a one-time loading dose of 1000 mg, followed by 500 mg in six to eight hours. Then 500 mg is taken once a day for two more days. The standard dosage for malaria treatment in children is based on the child's weight.

    Chloroquine Dosage & Rx Info Uses, Side Effects