I was losing weight without trying before starting on the plaq - and seem to be gaining without changing much of anything - since then, other than increasing my activity. I also find that eating a lot of carbohydrates helps with the GI effects of the plaq and that can contribute to weight gain. Gonna have to bite the bullet and really get serious about dieting and see what happens. Almost any med that can cause weight loss can also cause weight gain. Methotrexate and plaquenil for ra 10-2 visual fields in plaquenil toxicity Hydroxychloroquine and skin rash Chloroquine canada Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine I've gained about 30 lbs over the past year since I've been on Plaquenil but also on Prednisone. However, half of that weight I gained even before I was diagnosed or went on meds. My metabolism pretty much stopped about 6 months before diagnosis. Even now, with things going so well, nothing I do helps. Diet, exercise, etc. This drug definitely does not cause weight gain or bloat, thank goodness! Steroids are what are infamous for doing that. I've seen some people say it causes stomach/gi problems, but I personally have had no side effects at all. And like Veej said, it's one of the safest long term drugs for lupus. want to know good stuff about plaquenil. The only thing that I could figure was it was from the Plaquenil so I stopped taking it. I had not changed my eating habits or my exercise habits during those 2 yrs. Does plaquenil make you gain weight Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings., Plaquenil and Weight gain DailyStrength How common is chloroquine retinopathyChloroquine blood plasma ratioHydroxychloroquine muscle toxicityPlaquenil weight loss Plaquenil can cause a condition called retinopathy. This condition is very rare, but most often happens to people taking high doses of Plaquenil for several years. Initially, you can notice a “ring” of impaired vision that can affect your ability to read, but eventually, this condition will affect your central vision which can often be. Buy Prescription Hydroxychloroquine Sulfate Plaquenil - Honeybee Health. Want to know good stuff about plaquenil - HealthBoards. Plaquenil and loss of appetite - Lupus - MedHelp. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. My weight gain is from the steroids I'm certain and not the Plaquenil. Are you on anything else to treat your lupus other than the Plaquenil? If you're on steroids that can be whats causing you to gain weight. I can't offer any advice on losing the weight if you come off the Plaquenil. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints.