Additionally, another exception occurred while executing the custom error page for the first exception. This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Chloroquine synthesis reaction Baseline reading for plaquenil therapy Quinine vs chloroquine Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydrochlorothiazide is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. It is chemically designated as 6-chloro-3,4-dihydro-2 H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide and it has the following structural formula Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. Hydroxychloroquine cyp Drug Development and Drug Interactions Table of Substrates., Hydrochlorothiazide - FDA prescribing information, side. Does plaquenil cause dizziness the longer you take itPlaquenil safer than fluoroquinolonesPlaquenil et douleurs articulairesRa med hydroxychloroquineMalaria chloroquine tablets WebMD provides information about interactions between Plaquenil Oral and selected-cyp2d6-inhibitors-metoprolol. of cytochrome P450 2D6 substrate metoprolol in humans. of hydroxychloroquine. Interactions between Plaquenil Oral and selected-cyp2d6-inhibitors.. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Hydroxychloroquine Plaquenil. Drugs that inhibit CYP3A4 enzymes may increase plasma levels of hydroxychloroquine. Proton pump inhibitors may antagonize the immunomodulating effects of hydroxychloroquine. 7. Additional known interactions between hydroxychloroquine and coadministered drugs may be described in the FDA-approved Full Prescribing Information for Plaquenil. 9. However, the mechanism of inhibition of chloroquine metabolism appears to be via CYP inhibition, and hydroxychloroquine is not a known CYP substrate; cimetidine inhibition of hydroxychloroquine metabolism has not been demonstrated. Ciprofloxacin Major Avoid coadministration of hydroxychloroquine and ciprofloxacin. Hydroxychloroquine. Once retinal toxicity from hydroxychloroquine occurs, it is thought that the retinal changes are permanent and the disease can progress even if hydroxychloroquine is stopped for 1 to 3 years. Newer techniques for evaluation of retinal disease have been developed and these techniques can detect retinal toxicity earlier.