This type of malaria medication consists of two different drugs, one called chloroquine phosphate and one called proguanil hydrochloride, that are taken as two separate tablets but are packaged together. The two drugs are taken in combination to be more effective against malaria and as a form of malaria treatment, by inhibiting the reproduction of the parasites responsible for causing malaria. Chloroquine antimalarial side effects Plaquenil discontinued Does chloroquine and proguanil protect against malaria? Although chloroquine is an antimalarial, it is often not sufficient for prophylaxis. Chloroquine used to be the antimalarial of choice and it was widely used for from 1947 onwards. As a result, the malaria parasites endemic to certain regions developed a resistance to chloroquine. Question Some of my pregnant patients wish to travel to malaria-endemic regions. Are there medications that can be used safely during pregnancy for malaria prophylaxis? Answer Pregnant women should avoid travel to malaria-endemic areas if possible. However, if travel cannot be avoided, measures to prevent mosquito bites, along with an effective. Prevention of Malaria. Malarone is indicated for the prophylaxis of Plasmodium falciparum malaria, including in areas where chloroquine resistance has been reported. Treatment of Malaria. Malarone is indicated for the treatment of acute, uncomplicated P. falciparum malaria. Malarone has been shown to be effective in regions where the drugs chloroquine, halofantrine, mefloquine, and amodiaquine may have unacceptable failure rates, presumably due to drug resistance. In some countries, chloroquine proguanil medication requires a prescription, and in other places it is available without a prescription, but it is recommended to consult a doctor before taking any malaria medication. Both these drugs can have serious side effects, especially when taken together, including itching, skin rash, stomach pain, bloody stool, and hair loss. Chloroquine-proguanil malaria prophylaxis CHLOROQUINE WITH PROGUANIL Drug BNF content published by NICE, Prophylactic use of antimalarials during pregnancy Chloroquine life cycleEvaluation while on hydroxychloroquine Chloroquine and Proguanil Malaria Prophylaxis Liverpool School of Tropical Medicine CHLOROQUINE Adult dose is 2 tablets taken once weekly. Other name Avloclor 155mg base. Child dosage of Chloroquine is according to weight. Chloroquine is available in a liquid form from a Chloroquine and Proguanil Liverpool School of Malaria.. Malarone - FDA prescribing information, side effects and uses. Chloroquine & Proguanil Anti-Malarial Tablets. Jun 29, 2012 Blood Stage Prophylaxis In Vivax Malaria. Blood stage prophylaxis is the most common type of prophylaxis in use. Chloroquine, was the first drug in this group to be extensively used. It was introduced in the early 1950’s for the prevention of both falciparum and vivax malaria. For destinations where malaria cases occur sporadically and risk for infection to travelers is assessed as being low, CDC recommends that travelers use mosquito avoidance measures only, and no prophylaxis should be prescribed see Chapter 2, Yellow Fever Vaccine & Malaria Prophylaxis Information, by Country. In a third active-controlled study, MALARONE n = 110 was compared with chloroquine/proguanil n = 111 for the prophylaxis of malaria in 221 non-immune pediatric patients 2 to 17 years of age. The mean duration of exposure was 23 days for MALARONE, 46 days for chloroquine, and 43 days for proguanil, reflecting the different recommended.