Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take leflunomide with all of your drugs and health problems. Plaquenil mechanism of action in lupus Chloroquine diphosphate and penicillin Plaquenil generic approval date Plaquenil dosage for ra Leflunomide Arava® may also raise your risk of getting infections. Let your doctor know if you have signs of an infection, like fever or chills. Hydroxychloroquine Plaquenil® Hydroxychloroquine Plaquenil® is used for rheumatoid arthritis and systemic lupus erythematosus. Learn about drug interactions between hydroxychloroquine oral and leflunomide oral and use the RxList drug interaction checker to check drug combinations. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Leflunomide and hydroxychloroquine Rheumatoid Arthritis Medication Beware of Sunburn if You Take These., Hydroxychloroquine oral and leflunomide oral Drug Interactions - RxList Lupus drug plaquenilPlaquenil rheumatoid arthritis remissionPrimaquine and chloroquinePlaquenil white hair Hydroxychloroquine in vitro most strongly inhibits proliferation of B-cells, production of CXCL13, IFN-α, and immunoglobulins. Their combination additively decreases lymphocyte proliferation and cytokine- and immunoglobulin production. Since leflunomide and hydroxychloroquine combination therapy Additive immunosuppressive effect of leflunomide and hydroxychloroquine.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. FDA Drug Safety Communication New boxed warning for severe.. Caution should be used when leflunomide is given with other drugs that have the potential to cause liver injury. hydroxychloroquine, acetaminophen, non-steroidal anti-inflammatory drugs, and. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid arthritis RA. This study evaluates the efficacy of the combination of methotrexate and hydroxychloroquine against leflunomide, a new DMARD as initial therapy in severe active rheumatoid arthritis. Hydroxychloroquine is known to increase the potency of methotrexate as well as increase its safety profile and reduce the dose.