Chloroquine treatment and virus infection

Discussion in 'Canadian Pharcharmy' started by Vladimir_ULC, 01-Mar-2020.

  1. sudmed XenForo Moderator

    Chloroquine treatment and virus infection


    In a three-page paper published in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology wrote that both Chloroquine and the antiviral Remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. According to the paper, an efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections.

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    Although inhibitory in vitro, chloroquine as a prophylactic treatment in NHPs enhances CHIKV replication and delays cellular and humoral response. In patients, curative chloroquine treatment during the acute phase decreases the levels of key cytokines, and thus may delay adaptive immune responses, as observed in NHPs, without any suppressive effect on peripheral viral load. The Lead for clinical management in the WHO Health Emergencies Programme, Dr Janet Diaz said that there are currently no proven therapies for the new virus. Additionally, she said there is no proof to claims by some scientists that Chloroquine, can be a potential treatment for the infection. HUGE! New Study Reveals Taking Chloroquine Fights Off COVID-19 in 6 Days and Works as Preventative for Coronavirus Infection On Monday Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, announced that the first trial vaccine for the coronavirus is now being tested.

    Among the tested drugs, two compounds – remdesivir and chloroquine – potently blocked virus infection at low-micromolar concentration and showed high SI, it was revealed. Several FAD-approved drugs were tested, including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir and favipiravir against a clinical isolate of 2019-n Co V (coronavirus) in vitro.

    Chloroquine treatment and virus infection

    Could an old malaria drug help fight the new coronavirus?, Chloroquine Does NOT Cure Coronavirus! Dubawa

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  3. Chloroquine can affect virus infection in many ways, and the antiviral effect depends in part on the extent to which the virus utilizes endosomes for entry. Chloroquine has been widely used to treat human diseases, such as malaria, amoebiosis, HIV, and autoimmune diseases, without significant detrimental side effects 15.

    • Chloroquine is a potent inhibitor of SARS coronavirus..
    • HUGE! New Study Reveals Taking Chloroquine Fights Off COVID..
    • Medicines for the Prevention of Malaria While Traveling..

    Chloroquine is cheap and has been on the market for many years. It therefore may potentially be a good treatment option until a vaccine against the coronavirus is available. Chloroquine has been marketed internationally since 1934 as an antimalarial treatment. Invitro studies have documented the role of Remdesivir and Chloroquine in controlling the novel Coronavirus infections. The authors have concluded that these two agents are highly effective in vitro studies. Why not Chloroquine or Ritonavir? Although three drugs were found to be effectively inhibiting the coronavirus at the cellular level. Remdesivir is being thought of as the drug of choice as if it has cured many patients. This interim guidance is for clinicians caring for patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 SARS-CoV-2, the virus that causes coronavirus disease COVID-19. This update includes additional information from recent reports including Characteristics of.

     
  4. dr0fnax Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil Side Effects Common, Severe, Long Term - Plaquenil and skin discoloration - Sjogren's World Drug-induced nail disease DermNet NZ - All about the skin
     
  5. SPX Guest

    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Chloroquine Drug Information - Indications, Dosage, Side. Aralen Chloroquine Uses, Dosage, Side Effects. Chloroquine Oral Uses, Side Effects, Interactions, Pictures.
     
  6. vot Guest

    Hydroxychloroquine-Induced Retinal Toxicity - American. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful.

    RCOphth guideline Hydroxychloroquine and Chloroquine Retinopathy NEW.