I can say that the prednisone wean was successful, even after having only been on plaquenil a few months. To answer some of your other questions, it was the same timeframe for me. Plaquenil and toradol Icd 10 plaquenil ophthalmology Plaquenil itchy hands and feet Side effects include digestive problems, skin rash and disorders of skin pigmentation. One of the most serous side effects includes disorders of eyesight. The side effects related to the eyesight are blurred vision, sensitivity of the eyes to sun light, decreased night or color vision, decreased ability to see objects at the edge of vision, black spots in the vision or light flashes or streaks. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. But I couldn't handle the heart issue and not being able to breathe (plus all the other pains). Yesterday would've been my 4th day at the reduced dose. Plaquenil withdrawal side effects Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Hydroxychloroquine Plaquenil Chloroquine glycosylationPlaquenil testing optometryHydroxychloroquine sulfate 1gPlaquenil drug manufacturer Of the six patients withdrawn from the study because of a severe exacerbation of disease activity, a single patient in the hydroxychloroquine group and two in the placebo group were withdrawn because of severe exacerbations of polyarthritis, constitutional conditions, or mucocutaneous manifestations. A Randomized Study of the Effect of Withdrawing Hydroxychloroquine.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Plaquenil oral Reviews and User Ratings Effectiveness.. Ocular/eye damage is a side effect of Plaquenil seen especially with long term use of medication. Once damage to the eyes are noted, recommendation is to discontinue the medication, as further use can only worsen the ocular damage. Check with your doctor immediately if any of the following side effects occur Incidence not known. Blistering, peeling, loosening of the skin blurred vision or other vision changes chest discomfort, pain, or tightness cough or hoarseness dark urine decreased urination defective color vision diarrhea difficulty breathing Hello all, I am currently new to this site and ran across the discussion about stopping Plaquenil. I have been taking Plaquenil for about 8-9 months and thought that it was not helping me because I still have a fair amount of joint pain, fatigue, muscle pain and so many other issues.