Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Can plaquenil discolor yiur skin What is plaquenil side effects PANCREATIC CANCER A rare but aggressive cancer. The pancreas is a vital organ that makes insulin and other hormones, which aid in a number of processes important for good health. While it accounts for only 2% of cancers diagnosed in the United States each year, pancreatic cancer is the 3rd most common cause of cancer-related deaths in the country. Pancreatic cancer is associated with a hypercoagulable state resulting in a high risk of venous thromboembolism VTE, which affects up to 40% of patients during their course of disease 1,2,3. Development of VTE in patients with pancreatic cancer is associated with a poor prognosis 4, 5. Despite various approaches for thromboprophylaxis, both VTE and subsequent treatments for it are. Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with. In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Chloroquine and pancreatic cancer Gambogic acid induces autophagy and combines synergistically with., Chloroquine reduces hypercoagulability in pancreatic. Reducing inflammation without plaquenilCan plaquenil help osteoarthritisPlaquenil fullfield erg severeVision changes to watch for on plaquenilDoes plaquenil help psoriatic arthritis Any prior radiotherapy or combined radio-chemotherapy for pancreatic cancer if completed less than 12 months prior to study inclusion. Known hypersensitivity to trial drugs or hypersensitivity to any other component of the trial drugs. Known glucose-6-phosphate dehydrogenase deficiency. Concurrent use. Adjuvant Effect of Chloroquine on Gemcitabine - Full Text.. Combination of ERK and autophagy inhibition as a treatment.. Chloroquine reduces hypercoagulability in pancreatic cancer.. Chloroquine's potential chemosensitizing and radiosensitizing activities in cancer may be related to its inhibition of autophagy, a cellular mechanism involving lysosomal degradation that minimizes the production of reactive oxygen species ROS related to tumor reoxygenation and tumor exposure to chemotherapeutic agents and radiation. Pancreatic cancer cell line PaTu II 12, the effects of chloroquine on tumor growth were later. confirmed in mouse models of PDAC and attributed to the inhibition of autophagy 13, which is. responsible for recycling bioenergetic components to ensure cell survival in nutrient-deprived. times or locations 13. Following a previously published pre-clinical validation, this phase I study evaluated the safety, maximum tolerated dose, anti-tumour activity and immune status of a gemcitabine–chloroquine combination as a first- or late-line treatment in patients with metastatic or unresectable pancreatic cancer.