Drugs for chloroquine resistant malaria

Discussion in 'Canadian Pharmacies' started by Xella, 28-Feb-2020.

  1. Artembs Well-Known Member

    Drugs for chloroquine resistant malaria


    Artemisinin based combination therapies or ACTs, introduced in the 1990s, are the most effective drugs we have ever had to treat malaria. Artemisinin, taken from the sweet wormwood plant (Artemisia annua), is used in combination with other anti-malarial drugs.

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    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s. DRUG RESISTANT MALARIA Chloroquine resistance Chloroquine is ineffective in almost all malaria endemic countries In India chloroquine resistance was first detected in 1973 in Assam. Severe in northeast and southeastern regions of India with high morbidity and mortality. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies.

    In Southeast Asia, however, some malaria parasites have developed resistance to artemisinin-based drugs. Although artemisinin usually kills all malaria parasites, the use of a combination of drugs – as opposed to one – helps ensure that any parasites that remain will be killed by the other drug before the resistant parasites can spread.

    Drugs for chloroquine resistant malaria

    Malaria Drug Resistance Worldwide Antimalarial., DRUG RESISTANT MALARIA CURRENT STATUS

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  6. Following the war, chloroquine and DDT emerged as the two principal weapons in WHO’s global eradication malaria campaign. Subsequently, chloroquine resistant P. falciparum probably arose in four separate locations starting with the Thai-Cambodian border around 1957; in Venezuela and parts of Colombia around 1960; in Papua New Guinea in the.

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    Drug-resistant P. vivax. Chloroquine-resistant P. vivax malaria was first identified in 1989 among Australians living in or traveling to Papua New Guinea. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine is used to treat and to prevent malaria. Chloroquine is also used to treat amebiasis infection caused by amoebae. Chloroquine may also be used for purposes not listed in this medication guide. Jan 10, 2020 Piperaquine, is another antimalaria drug that is structurally related to chloroquine and is now used in combination with dihydroartemisinin. Piperaquine also accumulates in the digestive vacuole and prevents the detoxification of haem to haemozoin.

     
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  8. [email protected] XenForo Moderator

    Plaquenil, hydroxychloroquine (HCQ), is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other inflammatory and autoimmune diseases. Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Hydroxychloroquine Plaquenil
     
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    Hydroxychloroquine User Reviews for Lyme Disease, Arthritis. Oct 06, 2017 Plaquenil hydroxychloroquine "I felt better than I have in 20 years! After 20 years on NSAIDS needed for Lyme arthritis, my kidneys were affected, and when I stopped NSAIDS cold turkey, it was amazing how much pain my body was in. Now a year into Plaquenil I feel like a new person. Get eyes checked every 6 months.

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  10. ferer XenForo Moderator

    Let me tell you what weaning down from Plaquenil is like. I believe it is like any other drug, side effects can and do happen, but they are very individualized. I would like to be able to keep taking plaquenil, I just want to reduce my dose by half. I had no idea it was going to so profoundly impact me, and I guess I feel like I need to understand why.

    What is the correct way to discontinue use of plaquenil?