Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Filler used in hydroxychloroquine Plaquenil eye damage symptoms Studies have shown that patients who have manifested with retinopathy have traces of Plaquenil metabolites in their erythrocytes, plasma, and urine even after 5 years of discontinuing the medication 1, 2, 3. After 5 years of therapy, an ocular examination, 10-2 threshold field testing and any one objective testing is recommended 1, 4. Most screening guidelines recommend screening for HCQ/CQ retinopathy after 5 years of drug therapy with annual screening. Baseline evaluation, in some form, is widely recommended to identify those. IMPORTANCE Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Hydroxychloroquine retinopathy after short-term therapy Hydroxychloroquine Retinopathy Still Alive and Well - The., Hydroxychloroquine retinopathy Eye Neuropathy caused by plaquenilMethotrexate plaquenil and alcohol Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull's eye maculopathy. Increased Risk for Toxic Retinopathy With Long-Term.. The risk of toxic retinopathy in patients on long-term.. PDF Hydroxychloroquine Retinopathy - ResearchGate. Purpose To report an unusual case of hydroxychloroquine toxicity after short-term therapy. Methods Observational case report. Results A 56-year-old woman presented to the Ophthalmology Clinic at Walter Reed Army Medical Center WRAMC with a 6-month history of gradually decreasing vision in both eyes. The patient had been taking hydroxychloroquine for the preceding 48 months for the. Vision loss typically is permanent, with little significant improvement, and may continue to progress even years after drug cessation. Previous Plaquenil Testing Guidelines In 2002, the American Academy of Ophthalmology AAO established ocular examination guidelines for screening patients on Plaquenil therapy. Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis. Hydroxychloroquine comes with risks if you.