On chikungunya acute infection and chloroquine treatment

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  1. Nikey XenForo Moderator

    On chikungunya acute infection and chloroquine treatment


    The fever is usually above 39 °C (102 °F) and sometimes reaching 40 °C (104 °F) and may be biphasic—lasting several days, breaking, and then returning. Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase.

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    May 17, 2018 Clinical, biological, and immunological data were compared between treated and placebo groups. Acute CHIKV infection was exacerbated in NHPs treated with prophylactic administration of chloroquine. These NHPs displayed a higher viremia and slower viral clearance p 0.003. These chronic signs of chikungunya are disabling and merit further attention, because there is currently no recommended treatment for chikungunya based on clinical trials 10 111213. Treatment instead depends on the response of the patient, ranging from non-steroidal anti-inflammatory drugs. Due to the alkalisation of endosomes, chloroquine was an effective in vitro treatment against Chikungunya virus when added to Vero cells prior to virus exposure. The mechanism of inhibition likely involved the prevention of endocytosis and/or rapid elevation of the endosomal pH and abrogation of virus–endosome fusion.

    However, headache, insomnia and an extreme degree of exhaustion remain, usually about five to seven days. When Ig M, an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish.

    On chikungunya acute infection and chloroquine treatment

    Symptoms, Diagnosis, & Treatment Chikungunya virus CDC, Chikungunya Disease and Chloroquine Treatment

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  6. Chikungunya virus infection may resemble other illnesses such as dengue fever, Zika virus, malaria, mononucleosis, strep, and others, and it is important to rule out other causes for symptoms and signs. There is no specific medical treatment for chikungunya virus infection. Treatment is generally home remedies such as rest, fluids, and over-the-counter pain and fever medicines aimed at relief of symptoms and signs.

    • Chikungunya Virus Infection Symptoms, Prevention & Transmission.
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    • On Chikungunya Acute Infection and Chloroquine Treatment..

    Chloroquine. Chloroquine is theoretically effective against chikungunya virus by means of inhibition of viral enzymes, prevention of virus entry, impairment of viral maturation, or by enhancement of the immunologic response to the infection. An old open pilot study in 10 patients receiving chloroquine. Sep 15, 2009 Treatment for chikungunya fever is limited to supportive care rest, fluids, antipyretics, and analgesics. Although there have been in vitro studies and limited clinical data suggesting a role for certain drugs, such as chloroquine, acyclovir, ribavirin, interferon-α, and corticosteroids. Currently, no specific treatment for chikungunya is available. Supportive care is recommended, and symptomatic treatment of fever and joint swelling includes the use of nonsteroidal anti-inflammatory drugs such as naproxen, non-aspirin analgesics such as paracetamol acetaminophen and fluids.

     
  7. SKavenger XenForo Moderator

    : September 14, 2016 Chief complaint: Whirling and flashing lights A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. Plaquenil/Hydroxychloroquine - which eye tests do. - HealthUnlocked Plaquenil - Wellish Vision Institute Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.
     
  8. Kostya-5 XenForo Moderator

    Effects of chloroquine on viral infections an old drug against today's. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best.

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