Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Effect of chloroquine injection Chloroquine autophagy mice Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. In this review, we analyze Plaquenil side effects by the time on the drug, gender and age of the people who have side effects while taking Plaquenil. The review is based on 57,733 people who have side effects while taking the drug from Food and Drug Administration FDA. The information that eHealthMe analyzes includes Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil side effects skin rash Plaquenil hydroxychloroquine 200mg is it causing itchy., Common Plaquenil side effects a study from FDA data - eHealthMe Painful muscle spasms from plaquenilInformation on plaquenil Side effects include nausea, vomiting, diarrhea, hemolysis destruction of red blood cells in G6PD deficient patients patients low in this enzyme are more likely to break down red cells as a reaction to Plaquenil, visual abnormality uncommon, discoloration of skin bluish-gray, vertigo, weakness, and irritability. Rashes, Skin Care and Cutaneous Lupus What You Should Know. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Taking Plaquenil for Rheumatoid Arthritis. Sep 13, 2019 Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine MORE COMMON side-effects include Nausea & diarrhea – Plaquenil agrees with most people. Rarely it can cause an upset stomach or diarrhea. Skin rash – Plaquenil can rarely cause a rash. Patients who experience this rare side effect should stop taking this medicine and contact their doctor. Headaches – Plaquenil can rarely cause a headache. What are the side effects of Plaquenil? The most common side effects are diarrhea, nausea, vomiting, headache, dizziness, skin rash or black spots when you look at things. Most side effects will go away when your body gets used to the medicine. Tell your doctor if you have these side effects. A lower dose may stop them.