Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine diphosphate side effects Plaquenil full prescribing information Mechanism of action of hydroxychloroquine in rheumatoid arthritis Plaquenil itchy skin What will happen if you stop taking plaquenil? Wiki User November 17, 2011 PM. I was wondering what would happen when you stop taking plaquenil after trying it out for 3- 6 months. Plaquenil is supposed to stay in your system for 1-2 months after you stop taking it. Try to rest, stay hydrated and away from sick ppl for now and hopefully you will not have any issues It would be unlikely IMO that the Plaquenil is the cause, since there is tapering necessary when stopping it and no documented 'withdrawal' syndrome associated with it. If you have taken it for a long time, it is probably not even out of your system yet, since Plaquenil has a half-life of 30-60 DAYS not hours. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. What happens if you quit taking plaquenil What Are The Side Effects Of Stopping Methotrexate?, Stopping Plaquenil - General Discussion - Life With Lupus Molecular weight of chloroquine phosphateIs plaquenil safe to useCan plaquenil cause eye rednessDrug interaction plaquenil and doxycyclinePlaquenil louiville ky ob I was just curious if i was to try plaquenil again for a few days/weeks if you decide to stop do you have to wean off like a lot of drugs or can you simply stop taking it.thanks. Can you just stop taking plaquenil or do you have to wean off.. Plaquenil Withdrawal?. Plaquenil Uses, Dosage & Side Effects -. Aug 28, 2012 How long does it take for imuran and plaquenil hydroxychloroquine to completely leave your system if you stop them after taking thrm for 1 month. Dr. Stated plaquenil hydroxychloroquine could also be the reason for my vertigo - could vertigo really start 8 months after taking it? I don't want to stop this drug. We study 48,911 people who have side effects while taking Plaquenil from Food and Drug Administration FDA. Among them, 3 have Alcohol interaction. Find out below who they are, when they have Alcohol interaction and more. You are not alone. eHealthMe can help you improve drug uses, prevent side effects, and save money when you take medications. I recently decided to stop taking Plaquenil because I was having constant chest pains even more so than I usually have due to Lupus. Since I have not taken it my chest feels so much better which is odd because chest pain is not listed as a side effect. Also I noticed that the Plaquenil I think was making me feel different but not in a good way.