It typically happens in the evening or nighttime hours when you're sitting or lying down. Restless legs syndrome, also known as Willis-Ekbom disease, can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities. Discontinuing plaquenil Plaquenil free trial offer Plaquenil is a prescription medication used to reduce pain and swelling caused by diseases of the immune system such as rheumatoid arthritis, juvenile arthritis, and systemic lupus erythematosus SLE. This medication belongs to a group of drugs called DMARDs disease modifying antirheumatic drugs which work by suppressing the excessive activity of the immune system. The heat and pain from burning feet syndrome may become more intense at night and may not only involve the soles of the feet, but also the tops of the feet, ankles, and even the lower legs. Burning feet syndrome, also known as Grierson-Gopalan syndrome, is a set of symptoms in which the feet often become uncomfortably hot and painful. Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Medications also help many people with symptoms as abnormal, unpleasant sensations in their legs or feet. They do, however, consistently describe the desire to move their legs. Sometimes, symptoms disappear for periods of time, then come back. Simple self-care steps and lifestyle changes may help relieve symptoms. The sensations, which generally occur within the limb rather than on the skin, are described as: usually don't describe the condition as a muscle cramp or numbness. Plaquenil heavy legs How to Avoid Having Heavy Legs & Swelling of Ankles., Burning Feet Syndrome Grierson-Gopalan Syndrome Chloroquine dosage adultUlcer plaquenilWhat can you take instead of plaquenil I have been on 400 mg daily of Plaquenil, last week my doctor took me off of it ue to increase in the pain I had been having in lower back and unbelievable pain in my left leg and especially the extreme pain in the heel of my left foot. It was becoming painful to walk. After 5 days of stopping pain was 80% better. Plaquenil can cause back and leg pain? What type?. Plaquenil Uses, Dosage & Side Effects -. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Have any of you considered Lyme disease. The heavy arms and legs are a symptom of that also. Many people with lyme have been misdiagnosed with lupus and fibro and MS and many other things. I am just throwing it out there. I was just about to go on the Lyme board and saw the title "heavy arms and legs" it caught my eye. I have that symptom as. Jun 25, 2013 hydroxychloroquine is the generic form of Plaquenil but the side effects are the same. My thigh muscles are so sore I can hardly walk, sit or stand. Stairs are a TRUE challenge. I have to struggle up and down taking only one step at a time using only one leg at a time. I am also suffering from RA and fibromyalgia. My legs and arms also feel very heavy and numb at times. I try to accomplish one goal a day, and maybe more if I can. I am taking Humira and Plaquenil for the RA and Lyrica for the fibromyalgia. They seem to help, but of course I have good days and bad days.