Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Plaquenil and citalopram qt prolongation Hydroxychloroquine and sulfasalazine combination The mechanism of toxicity is unknown but is thought to be due to accumulation of the medication in the retinal pigment epithelium RPE, leading to subsequent RPE degeneration. 1 Because of this theorized accumulation, hydroxychloroquine toxicity can progress despite cessation of the medication. 1,2 Apr 02, 2019 However, a very close eye needs to be kept on this child as life-threatening toxicity may evolve rapidly. It is prudent to intubate a patient with a potentially significant chloroquine overdose if there is any significant depression of consciousness level or cardiovascular instability. The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine eye toxicity Chloroquine retinopathy - Wikipedia, Chloroquine poisoning • LITFL • Clinical Case Tox Conundrum Plaquenil depletes magnesiumAvkare plaquenilHydroxychloroquine lung cancerChloroquine hcl200 mg of plaquenil how long to work Color photograph of left eye documenting end-stage chloroquine retinal toxicity, with disc pallor, vascular attenuation, diffuse pigment mottling, and pigment deposition along the peripheral retinal vessels similar to retinitis pigmentosa. Visual acuity was 20/200. Chloroquine Retinopathy - an overview ScienceDirect Topics. What can Hydroxychloroquine Plaquenil do to my eyes?. Chloroquine C18H26ClN3 - PubChem. By 2/2010 things were so dim I could not see to shop in stores. I quit taking Plaquenil but the DR still said no toxicity. My eyes continued to get worst. In tears I went back in July he finally sent me to a retina specialist. You don't have to have Bulls eye damage to have toxicity Over weight women over 60 should beware of taking Plaquenil. Jul 30, 2019 The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia. Mar 15, 2019 The mechanism of chloroquine and hydroxychloroquine toxicity is not well understood. Chloroquine has an affinity for pigmented melanin-containing structures, which may explain its toxic properties in the eye. Melanin serves as a free-radical stabilizer and can bind toxins, including retinotoxic drugs.