Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Side effects from stopping plaquenil Chloroquine classification Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Nov 15, 2015 Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. Jan 05, 2020 Hydroxychloroquine binds to melanin, accumulates in the RPE, and remains there for long periods of time. It is directly toxic to the RPE, causing cellular damage and atrophy 2. This occurs due to disruption of RPE metabolism, specifically from lysosomal damage 5, and reduced phagocytic activity toward shed photoreceptor outer segments. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine mechanism Hydroxychloroquine Oral Route Precautions - Mayo Clinic, Chloroquine & Hydroxychloroquine supporting chemo. Another medication that can be taken with plaquenil Mechanism of action. Hydroxychloroquine is weakly basic, which permits its uptake and concentration in a nonionised form within cells. Having entered the lysosomes inside the cell, the acidic environment traps and concentrates the drug in its ionised state. Hydroxychloroquine - an overview ScienceDirect Topics. Hydroxychloroquine toxicity - EyeWiki. Hydroxychloroquine Information for Providers AIDSinfo. Hydroxychloroquine and diabetes drugs all decrease your blood sugar level. Taking hydroxychloroquine with these drugs could cause hypoglycemia low blood sugar. Mechanism Hydroxychloroquine is thought to improve symptoms of systemic diseases by preventing inflammation. For example, to treat both rheumatoid arthritis and systemic lupus erythematosus SLE, it has been hypothesized that the drug suppresses T-lymphocytes by increasing the pH inside lysosomes, which disables leukocyte chemotaxis. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus.