If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Plaquenil and artemisia annua together Chloroquine price in india Treatment of porphyria cutanea tarda with chloroquine The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. The dosage is based on body weight. 6.5 mg/kg maximum dose 400 mg should be given on the same day each week starting 2 weeks before exposure to malaria. SAN FRANCISCO – Hydroxychloroquine Plaquenil dosing based on actual body weight – instead of ideal weight – is appropriate for patients with systemic lupus erythematosus SLE, according to a review of 686 lupus patients at Johns Hopkins University in Baltimore. Most were dosed by actual weight, 6.5 mg/kg up to a maximum of 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dose based on weight Hydroxychloroquine Oral Route Proper Use - Mayo Clinic, Hydroxychloroquine Side Effects, Dosage, Uses, and More Plaquenil macular degenerationChloroquine toxicity of retinaSymptoms of eye side effects from plaquenil Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended. Plaquenil hydroxychloroquine sulfate dose, indications, adverse.. ACR Actual-weight hydroxychloroquine dosing works in SLE.. Plaquenil Risk Calculators. The recommended dose was subsequently lowered based on the patient’s weight which helps to prevent retinopathy over time. We also request a detailed baseline eye exam which includes color vision and visual field-testing, and repeated every 6-12 months to detect the earliest changes in the retina which may be reversible by stopping or reducing. Jan 03, 2020 Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7.