The cramping, cold sweats, and explosive diarrhea was unimaginable. Its my classic reaction to all new psych drugs and new antiseizure drugs, including neurontin. It is a pain in the you kno what, but I have to do what I have to do! I thought I was going to pass out the pain was so bad. Plaquenil itself I've never had an issue with, but there was a med I was given for a UTI that I didn't know was NOT supposed to be with food that gave me that kind of reaction. I wasn't too bad with Plaquenil until I doubled the dose a few weeks ago to 400mg. Plaquenil prevents lupus anticoagulangpt antibodies When was plaquenil invented Aug 18, 2009 I thought that plaquenil was more processed by the kidneys than the liver and the problem you describe is what my gi doc calls "dumping" when the liver can't handle the med and acts like its poison and you get explosive diarrhea as your body tries to get rid of it. Hydroxychloroquine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away headache; dizziness; loss of appetite; nausea; diarrhea; stomach pain; vomiting; skin rash; If you experience any of the following symptoms, call your doctor immediately Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Hopefully, it's like Lynwood said - a one time anomaly. I didn't think it was going to be like this though! I really have to shift the burden off my liver whenever I can. Love, Marji I am going on week three with the plaq and I have worked out a little routine. I did give myself a much needed cleanse though..... You might want to check the website it's a great drug interaction website that also checks some foods & seasonings Sorry you had that nasty episode, I bet it's a one-time combo of some kind that did you in. Then I had explosive diarrhea I've settled down a bit but about once a week I have a really bad blow out. But I'm starting to feel a lot better with my other symptoms, so a little digestive discomfort is worth it I suppose. Can hydroxychloroquine cause diarrhea Plaquenil Oral Uses, Side Effects, Interactions., Hydroxychloroquine MedlinePlus Drug Information Is chloroquine related to malaronePlaquenil taken with uroxatral I can only tolerate one 200mg dose of plaquenil a day. I allergic to sulfa, and the full does causes my skin to break out in an itchy burning rash from scalp to toes, and everywhere in between. So, I do not have stomach issues, probably because of that. However, the methotrexate does cause some intestinal distress the following day. Plaquenil/Hydroxychloroquine and stomach problems?. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Talk with your doctor if you have fever, vomiting, or diarrhea during your treatment. When treating lupus or arthritis, hydroxychloroquine is usually given daily for several weeks or months. For best results, keep using the medication as directed. Hydroxychloroquine can cause serious liver or heart problems, especially if you use certain.