Those with APS make abnormal proteins called antiphospholipid autoantibodies in the blood. This causes blood to flow improperly and can lead to dangerous clotting in arteries and veins, problems for a developing fetus and pregnancy miscarriage. Retinal toxicity from plaquenil years after discontinued Chloroquine inhibits autophagy in host tissues Hydroxychloroquin and methotrexate Zentiva hydroxychloroquine Signs and symptoms of antiphospholipid syndrome can include Blood clots in your legs DVT. Signs of a DVT include pain, swelling and redness. These clots can travel to your lungs pulmonary embolism. Repeated miscarriages or stillbirths. The diagnosis of antiphospholipid syndrome is made by testing the blood of patients with blood clots and/or recurrent miscarriages for the presence of anti-phospholipid autoantibodies aPL. Screening is done using three kinds of tests. Tests may vary because of the differences in the aPL from patient to patient. You can have antiphospholipid antibodies and never develop any signs or symptoms. A diagnosis of antiphospholipid syndrome is made only when these antibodies cause health problems. Treatment. If you have blood clots, standard initial treatment involves a combination of blood-thinning medications. The most common are heparin and warfarin. APS affects women five times more commonly than men. People with this disorder may otherwise be healthy, or they also may suffer from an underlying disease, most frequently systemic lupus erythematosus (commonly called lupus or SLE). Plaquenil for antiphospholipid syndrome Mechanism of Action of Hydroxychloroquine in the., Antiphospholipid Syndrome - Plaquenil side effects skin discolorationHow long does it take for chloroquine to workChloroquine and cancer Elective therapeutic approaches are required since recurrent thrombosis remains a major challenge in the management of antiphospholipid syndrome APS despite an efficient anticoagulation. Several data suggest that hydroxychloroquine HCQ could play a role in the prevention of thrombosis. Hydroxychloroquine as an anti-thrombotic in antiphospholipid.. Antiphospholipid syndrome - Diagnosis and treatment - Mayo.. Antiphospholipid Syndrome Treatment & Management Medical.. The antiphospholipid aPL syndrome APS is an acquired autoimmune thrombophilic condition that is a cause of pregnancy complications attributable to placental insufficiency including recurrent pregnancy losses and other including IUGR, oligohydramnios, preeclampsia/toxemia and placental abruption. 11 aPL antibodies reduced the levels of AnxA5 on placental villous SCTs, 12 cultured BeWo trophoblasts, 13–15 and primary cultures of SCTs, 14 and reduce the anticoagulant activity of AnxA5 on. Hydroxychloroquine HCQ was suggested to play a role in lowering antiphospholipid antibody titers and preventing thrombotic recurrences in patients with systemic lupus erythematosus, but few data are available in patients with primary antiphospholipid syndrome PAPS. Antiphospholipid Syndrome Support Group. Antiphospholipid syndrome or antiphospholipid antibody syndrome is a disorder of coagulation which causes thrombosis in both arteries and veins, as well as recurrent miscarriage. It is due to the autoimmune production of antibodies against cell membrane constituents.