Plaquenil induced hyperpigmentation

Discussion in 'Chloroquine Without A Doctor Prescription' started by Profdesign, 13-Mar-2020.

  1. oplot User

    Plaquenil induced hyperpigmentation


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    I think it's due to Hydroxycholoroquine-induced hyperpigmentation an example of drug-induced skin pigmentation. I thought it worth showing those of you on the medication. Why is it so much worse on the right forearm? Well she's only just started to drive again. The pathogenesis underlying chemotherapy-related dyspigmentation is not completely known, but some proposed mechanisms for this hyperpigmentation include direct stimulation of melanin production and postinflammatory hyperpigmentation after drug-induced toxicity to the keratinocytes. We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female case 1 and a 78-year-old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4-5 years.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Plaquenil induced hyperpigmentation

    Drug-Induced Hyperpigmentation Review and Case Series American Board., Drug-Induced Pigmentation Background, Pathophysiology, Etiology

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  6. Drug-Induced Hyperpigmentation caused by Plaquenil Hydroxychloroquine Plaquenil Hydroxycholoroquine Side Effects. Dermatologic side effects have included mucocutaneous hyperpigmentation, nonlight-sensitive psoriasis, bleaching of hair, alopecia, pruritus, photosensitivity, and skin eruptions such as urticarial, morbilliform, lichenoid, maculopapular, purpuric, erythema annulare centrifugum, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, and exfoliative dermatitis.

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    The antimalarials are one of the most commonly prescribed drugs in medical practice, for conditions such as rheumatoid arthritis as well as malaria. They are generally well-tolerated and the possible side effects of synthetic antimalarials, though Plaquenil and Skin hyperpigmentation - from FDA reports Summary Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. There was no pigmentation at other body sites.

     
  7. Badhead Well-Known Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Hydroxychloroquine Indications, Side Effects, Warnings.
     
  8. softcreator Moderator

    Chinese experts, based on the result of clinical trials, have confirmed that chloroquine phosphate, an antimalarial drug, has a certain curative effect on the novel coronavirus disease (COVID-19), a Chinese official said on Monday. Chloroquine Dosage Guide with Precautions - Chloroquine phosphate C18H32ClN3O8P2 - PubChem Chloroquine MedlinePlus Drug Information
     
  9. OlgaStarXXXL New Member

    Chloroquine Uses, Side Effects & Warnings - Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Chloroquine Oral Route Side Effects - Mayo Clinic
     
  10. Seolomon XenForo Moderator

    Patient Comments Lupus - Experience - MedicineNet I have been on Plaquenil for 5 months now and it has helped but I continue to have exhaustion, muscular aches and pains and now I've developed tachycardia needing a cardiologist evaluation. I've been diagnosed with fibromyalgia as well. There are days that I wish I could just stay in bed. I lost my job over Lupus.

    Plaquenil Drug and Medication User Reviews on RxList