Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Hydroxychloroquine does How long chloroquine tablets is good after expiration date Hydroxychloroquine in systemic lupus erythematosus SLE Ponticelli C 1 and Moroni G 2 1 MD, Senior Consultant Nephrological Unit, Humanitas Clinical and Research Center, Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. The many mechanisms for the hypoglycemic effects of antimalarials 10. These properties have demonstrated clinical efficacy in noninsu-lin-dependent patients, including those refrac-tory to sulfonylureas 11. Lupus patients benefit from these properties as well. In the Hopkins lupus cohort, for example, treatment with Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil lupus mechanism How is plaquenil hydroxychloroquine used to treat lupus?, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Block mhc chloroquine Hydroxychloroquine Plaquenil is also a disease-modifying anti-rheumatic drug DMARD used to treat both acute and chronic rheumatoid arthritis, systemic lupus erythematosus, and discoid lupus erythematosus. Hydroxychloroquine likely works in the prevention and treatment of malaria by interfering with the parasite's normal growth and replication process. Hydroxychloroquine Plaquenil Success, Reviews and Side Effects. Antimalarials in systemic lupus erythematosus benefits.. Hydroxychloroquine - an overview ScienceDirect Topics. Precise mechanism of action is not known. INDICATIONS PLAQUENIL is indicated for the suppressive treatment and treatment of acute attacks of malaria due to Plasmodium vivax, P. malariae, P. ovale, and susceptible strains of P. falciparum. It is also indicated for the treatment of discoid and systemic lupus erythematosus, and rheumatoid arthritis. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus.