It could be that your medication for rheumatoid arthritis or related syndromes is causing photosensitivity, a reaction of the immune system that can make you more susceptible to sunburns and sun rashes. If you don’t see yours here, be sure to ask your doctor; many other drugs, such as certain antibiotics, can cause photosensitivity, too. Plaquenil similar Ocular side effects of plaquenil Plaquenil and arava The topical hair growth drug minoxidil Rogaine can also cause scalp sensitivity in some people. The sun also can wreak havoc on the scalp. Like the rest of the skin, the scalp can sustain a sunburn, especially along a part line or in areas where the hair is thinning. Wearing a hat while outdoors is the best way to prevent a scalp sunburn. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. Sun-sensitive or photosensitive drugs are drugs that cause a moderate to severe skin reaction that is similar to a bad sunburn when exposed to the sun UV rays, usually the forehead, nose, hands, arms, and lips. Many common medications cause this reaction in some people. Some may be out of your system within 36 hours; others may take more or less time. Here are some of the culprits that are used to treat autoimmune disease, listed from most likely to cause a reaction to least: Everyone has to be careful in the sun, but if you're taking a sun-sensitive drug, you need to be extra rigorous — and these medication side effects are difficult to predict. Brodell, MD, professor and chair of the department of dermatology at the University of Mississippi Medical Center in Jackson, every drug has a different half-life, which means they each take a different amounts of time to clear your body. Plaquenil sun sensitivity tingling UV exposure What you need to know Lupus Foundation of America, Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs Can plaquenil cause dry mouthWhat is hydroxychloroquin used foPlaquenil skin side effects Bottom line is Lupus itself or UCTD or MCTD causes sun sensitivity. The sun is an irritant. Normal sunburn is an inflammation. Diseases like these give us overactive immune systems. Thus our overactive systems attack the sun exposure more forcefully than ever before. The inflammation is more severe -- we may get sun rash, sun poisoning, fever, fatigue, and various other symptoms with sun exposure. Sun reaction -. Sun-Sensitive Drugs Photosensitivity to Drugs - MedicineNet. Photosensitivity Reaction With Certain Medications. Numbness and tingling is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 1 month, also take medication Aredia, and have Osteoporosis Skin rashes occasionally develop and hydroxychloroquine may make you more sensitive to the sun, so it is advisable to use the usual precautions of sunscreens and a hat if you are in the sun. Also, your hair may become a little bleached with the drug and rarely a degree of thinning of the hair can develop. Feb 26, 2008 My tingling in the sun is caused by photosensitivity, which can be caused by lupus or some of the lupus medications. Tingling in arms, legs, hands, feet I've found to be minor neuropathy; basically a nerve inflammation that comes and goes with lupus activity.