History of chloroquine resistance

Discussion in 'Chloroquine' started by Tashha, 11-Mar-2020.

  1. Maltys User

    History of chloroquine resistance


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    As mentioned in the history section of this website, the first confirmed cases of chloroquine resistance CQR were documented in two Americans who return ed from Colombia in 1961 with resistant strains of P. falciparum. Resistance began to appear in Papua New Guinea in the 1960s and Africa in the 1970s 1. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Nov 25, 2019 Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    History of chloroquine resistance

    What Is Chloroquine Resistance? with picture, Chloroquine C18H26ClN3 - PubChem

  2. Reticulocytes chloroquine
  3. Hydroxychloroquine and chloroquine are medications traditionally prescribed to prevent or treat malaria infections. In certain countries and parts of the world where malaria is still present, a person can easily catch malaria from a seemingly insignificant mosquito bite.

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    A closer look at the genesis of chloroquine resistance along the Thailand–Cambodia border, which became ground zero for the emergence of chloroquine resistance in the 1950s and 1960s, reveals a. Chloroquine mechanism of drug action and resistance in Plasmodium falciparum. Slater AF1. Author information 1Picower Institute for Medical Research, Manhasset, NY 11030. Quinoline-containing drugs such as chloroquine and quinine have had a long and successful history in antimalarial chemotherapy. Development of Chloroquine Resistance in Plasmodium falciparum. Drug resistance is the ability of a parasite to survive despite the presence of a drug that is meant to kill it in toxic levels. Resistance developed by most parasites that were initially sensitive to drugs mostly result from mutations in the genes responsive to the drug.

     
  4. Serdjo New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Vaping during pregnancy Is it safe? - Mayo Clinic Chloroquine - Wikipedia Drug Safety in Pregnant & Nursing Women
     
  5. Pegospegesox Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Indications, Side Effects, Warnings - Contraindications for Chloroquine Medicines for the Prevention of Malaria While Traveling - Chloroquine.
     
  6. Peppito New Member

    Chloroquine Phosphate Tablet - Uses, Side-effects, Reviews, and. If you use other drugs or over the counter products at the same time, the effects of Chloroquine Phosphate Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly.

    Aralen, Chloroquine phosphate chloroquine dosing.
     
  7. atikin XenForo Moderator

    Hydroxychloroquine / Plaquenil and the Covid-19 / Coronavirus. Chinese found an In Vitro activity of Plaquenil, and maybe in Vivo too but the live study is not yet published. A Professor in France got interested in.

    Can plaquenil hydroxychloroquine for autoimmune disease.