It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Cheaper alternative to plaquenil Plaquenil and artemesia annua Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil dose for arthritis Hydroxychloroquine Plaquenil -, Plaquenil vs. Prednisone Prescription Treatment for. Lupus traitement plaquenilHeterocyclic ring present in chloroquineMilk thistle and plaquenil Your doctor will advise you about the correct dose. Usually you will start on a full dose of 200–400 mg daily, and later your doctor may reduce this. When your condition is very well controlled you may be advised to take hydroxychloroquine only 2–3 times per week. Hydroxychloroquine Side-effects, uses, time to work. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hydroxychloroquine dosage recommendations often ignored.. Dosage for rheumatoid arthritis Adult dosage ages 18 years and older Typical starting dosage 400–600 mg per day, given as a single daily dose or in two 2 divided doses. Two plaquenil a day and 2400 mg of ibuprofen a day that's 12 regular dose! and I went into total remission. Of course my stomach is crap now. After 25 years of remission, the RA returned. Adult dosing ranges from 200 mg or 400 mg per day 6.5mg/kg. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is recommended to be taken with food.