Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity. The image below depicts hydroxychloroquine retinopathy. Fluorescein angiogram of left macula in patient with hydroxychloroquine retinopathy. Plaquenil perioperative management Plaquenil 400 mg bid Has anyone experienced plaquenil toxicity with damage to eyes? Asked by barb2032 Updated 10 October 2019. frustration also as I don't think they diagnosed mine as quickly as they should have if there had been more extensive testing than the color blindness book. Since seeing a retina specialist and having the diagnosis made in May. Here are 10 things to keep in mind when using Plaquenil Take it on a regular schedule, meaning at the same time each day. Take Plaquenil EXACTLY as prescribed by your physician. Do not stop taking the medication without first speaking to your doctor. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. The most common tests to detect hydroxychloroquine toxicity have been visual acuity, visual fields Amsler grid, automated visual field, color vision testing, full-field electroretinography ERG, and multifocal electroretinography mfERG.6, 7 Because of the localized nature of the defects, mfERG seems to be better than the full-field ERG in. Retinopathy may be asymptomatic or may cause central or paracentral scotomas leading to difficulty reading or performing fine visual tasks (due to parafoveal metamorphopsia). Reprinted from American Journal of Ophthalmology, Vol 104, Johnson and Vine, Hydroxychloroquine therapy in massive total doses without retinal toxicity, pages 139-144, Copyright 1987, with permission from Elsevier Science. Color dx test results in plaquenil toxicity Retinal Physician - Hydroxychloroquine Maculopathy An., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Methotrexate vs hydroxychloroquineComing off plaquenil This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine-Induced Retinal Toxicity - American.. Detection of Early Hydroxychloroquine Retinal Toxicity.. New Plaquenil Guidelines. End stage hydroxychloroquine toxicity leads to widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision. Plaquenil, widely used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions, is very effective, and “the risk of toxicity in the first five years for someone without special risk factors is very low,” Dr. Marmor said. However, risk increases with duration of use. ColorDx® CCT HD® Color vision and contrast sensitivity are important functions of the visual system, which may be affected by many diseases, disorders and common substances. Understanding if, and how much these functions are affected, may assist clinical decision making and help doctors educate patients about the risks and consequences of.