Hydroxychloroquine overdose toxicokinetics and management

Discussion in 'Hydroxychloroquine 200 Mg Tab' started by Franklin, 09-Mar-2020.

  1. Libertytext Moderator

    Hydroxychloroquine overdose toxicokinetics and management


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    The management and toxicokinetics of hydroxychloroquine overdose are poorly described. We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. Hypokalemia is defined as a serum or plasma potassium that is less than the normal value. The etiology, clinical findings, diagnosis, evaluation, and management of pediatric hypokalemia are reviewed here. Brookes JG, Nikolic G, Le Couteur DG. Hydroxychloroquine overdose toxicokinetics and management. J Toxicol Clin Toxicol 1999; 1. Hydroxychloroquine is a 4-aminoquinoline derivative prepared by beta hydroxylation of chloroquine. It is used in the treatment of malaria, rheumatoid arthritis, and lupus erythematosus, and marketed under the name Plaquenil Sanofi Pharmaceuticals, New York, NY.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Hydroxychloroquine overdose toxicokinetics and management

    Novel Therapies for Myocardial Irritability following Extreme., UpToDate

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  6. Abstract Hydroxychloroquine poisoning has rarely been reported in the literature, with only 18 cases being found on searching the literature. In this paper, we report a case that occurred in Hong Kong, and we make recommendations for emergency management of hydroxychloroquine overdose based on our and other's experience.

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    • A case of fatal hydroxychloroquine overdose.

    Hydroxychloroquine – which has a similar toxicity profile – has largely superseded it for the treatment of rheumatoid arthritis. In overdose both chloroquine and hydroxychloroquine cause sodium channel blockade with primarily cardiovascular and central nervous system effects, as well as hypokalemia due to intracellular potassium shifts. BACKGROUND The management and toxicokinetics of hydroxychloroquine overdose are poorly described. CASE REPORT We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement. Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning 20 g in each case, both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium.

     
  7. Andrey_asd New Member

    Applies to chloroquine: oral tablet Along with its needed effects, chloroquine may cause some unwanted effects. Plasmodium species Malaria - Infectious Disease and. Chloroquine Oral Route Proper Use - Mayo Clinic Chloroquine Side Effects Common, Severe, Long Term -
     
  8. Maqeulek Moderator

    Hydroxychloroquine User Reviews for Rheumatoid Arthritis at. Hydroxychloroquine is a good drug for mild arthritis however length of time it takes for drug to leave body is worrying when you are faced with loosing your sight and possible progression after you stopped taking the drug. Also check the dose is correct for your ideal weight do you are not over medicated."

    Hydroxychloroquine - Wikipedia