I was diagnosed with discoid lupus 18 years ago and was prescribed Plaquenil, which I have taken since then. In October 2012, I was also diagnosed with Sjogrens Syndrome but, as I was already taking Plaquenil, was advised the treatment was the same for Sjogrens. Chloroquine resistance in p vivax Define hydroxychloroquine Yes, Plaquenil can cause aplastic anemia, agranulocytosis, leukopenia, anemia, thrombocytopenia. So yes, this could be the cause of your WBC count going down, and for anemia that you have. Apart from that it can also be due to anti-thyroid cancer drugs. Please discuss with your doctor, and see if some other drugs can be started for you. Take care! Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Low white cells are a part of the autoimmune issue. This is something that I have dealt with for years. I have been on the Plaquenil a couple of years now and my immunologist told me that Plaquenil doesn't cause the same issues as the DMARDS or the methotrexates, imuran, etc. From research I have done online, I gather that low white cell count can also be a symptom of the Sjogrens in itself. At a recent medical with my doctor, blood tests were taken and I had a call a couple of days later telling me to stop taking g Plaquenil immediately as I have a very low white cell count and that it is sometimes a side effect of Plaquenil. Hydroxychloroquine cause low wbc Low White Blood Cell Count Hi - been diagnosed. - LUPUS UK, Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria Plaquenil for dermatomyositisHydroxychloroquine nursing implicationsPlaquenil therapy icd 10 I took Plaquenil for 8 month, I started in November 2017 with 400 mg two months then I started 200 mg for 5 months. The count of white cells was 5.7 in November and in January was 3.7 and in May become 2.5 the decrease of white cells due to the use of Plaquenil tablet My email is [email protected] Does Plaquenil tablet reduce the count of white blood cells.. Link between low white cell count and taking Plaquenil?. Medications causing Low white blood cell count.. Medical use. Hydroxychloroquine treats malaria, systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever. In 2014, its efficacy to treat Sjögren syndrome was questioned in a double-blind study involving 120 patients over a 48-week period. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Call your doctor at once if you have So I'm wondering.after all this time, could it be starting to affect me adversely? To put it bluntly, I bloody well hope not. I know there are other causes for low white blood count, but I figured I'd see if anyone else has the experience with good long-term benzodiazapine use for seizure control as I have and if it's been the cause for low wbc.