The same generic drug, made by a different manufacturer, can indeed look different. A: Yes, it is confusing, and unfortunately, it's fairly common. What are chloroquine phosphate tablets used for Benlysta prednisone ldn and plaquenil for lupus Hydroxychloroquine in pregnancy Possible qt prolonging agents/hydroxyzine; possible qt prolonging agents/pimavanserin; tricyclic compounds/inhaled mixed-acting sympathomimetics; tricyclic compounds/inhaled direct-acting. The active ingredient, hydroxyzine, is the same in both formualtions, though the salt, pamoate or hydrochloride, to which it is attached is different. The pamoate comes as a capsule and the hydrochloride is a tablet. The release mechanism into the body is different between the two and hence why one may work better for you. Yes, both formulations have the same active ingredient hydroxyzine, BUT they are attached to 2 DIFFERENT salt forms Hcl which is found in the tablet form, and under the brand name "Atarax" vs. pamoate which is found in the capsule form, and under the brand name "Vistaril". The pamoate formulation is more lipophilic. Then, because pharmacies often change suppliersor their wholesalers doa pharmacy's own stock of a particular generic drug may continually rotate. Additionally, generic drug manufacturers can also take it a step further by producing generic pills that look different from another manufacturer's generics pills. Are hydroxyzine and plaquenil the same thing Benadryl vs Hydroxyzine Comparison -, Do Hydroxyzine PAM and Hydroxyzine HCL work for two. Chloroquine phosphate lethalItching plaquenil The study is based on hydralazine hydrochloride and hydroxyzine hydrochloride the active ingredients of Hydralazine hydrochloride and Hydroxyzine, respectively, and Hydralazine hydrochloride and Hydroxyzine the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered. Hydralazine hydrochloride and Hydroxyzine drug interactions.. What is the difference between hydroxyzine hcl and.. DOXYCYCLINE/PLAQUENIL - SO CONFUSED! - Road Back Foundation. By researching, I found information that hydroxyzine pamoate the capsule form crosses the blood/brain barrier, whereas hydroxyzine hydrochloride the tablet form does not. That could help to explain why one might cause someone to be susceptible to having seizures while the other one does not. Q I've been refilling the same generic drug prescription at my pharmacy for months without incident, but this month, I was given pills that are a different shape and color. The pharmacist says. Does Plaquenil Interact with other Medications? Severe Interactions. These medications are not usually taken together. Consult your healthcare professional e.g. doctor or pharmacist for more in.