Chloroquine cytokine

Discussion in 'International Pharmacy' started by swim7, 10-Mar-2020.

  1. sc100 Guest

    Chloroquine cytokine


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. Approved indication: For the suppressive treatment of malaria due to Plasmodium vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: 300 mg base (500 mg salt) orally once a week Comments: -For prophylaxis only in areas with chloroquine-sensitive malaria -Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly (same day each week) while in malarious areas and for 4 weeks after leaving such areas.

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    Whereas, Chloroquine Phosphate was banned in Nigeria 14 years ago, preliminary clinical results in China show that the anti-malarial drug is quite effective in treating novel coronavirus pneumonia. Several other antiviral drugs to treat the novel coronavirus outbreak in China that has claimed over 1,500 lives are under clinical trials and some have shown fairly The anti-inflammatory property of chloroquine CQ has long been recognized. This study aimed to investigate the effect of CQ on proinflammatory cytokine e The results showed that CQ treatment reduced the levels of tumor necrosis factor-α TNF-α, interleukin-6 IL-6, and CC chemokine ligand 2 CCL2 in culture medium but increased intracellular protein expression of TNF-α and CCL2 in SAC-activated cells. The anti-inflammatory property of chloroquine CQ has long been recognized. This study aimed to investigate the effect of CQ on proinflammatory cytokine expression in RAW 264.7 macrophages stimulated with heat-inactivated Staphylococcus aureus cells SAC. The results showed that CQ treatment reduced the levels of tumor necrosis factor-α TNF-α, interleukin-6 IL-6, and CC chemokine.

    Approved indication: For acute attacks of malaria due to P vivax, P malariae, P ovale, and susceptible strains of P falciparum CDC Recommendations: Chloroquine-sensitive uncomplicated malaria (Plasmodium species or species not identified): 600 mg base (1 g salt) orally at once, followed by 300 mg base (500 mg salt) orally at 6, 24, and 48 hours Total dose: 1.5 g base (2.5 g salt) Comments: -For the treatment of uncomplicated malaria due to chloroquine-sensitive P vivax or P ovale, concomitant treatment with primaquine phosphate is recommended. 60 kg or more: 1 g chloroquine phosphate (600 mg base) orally as an initial dose, followed by 500 mg chloroquine phosphate (300 mg base) orally after 6 to 8 hours, then 500 mg chloroquine phosphate (300 mg base) orally once a day on the next 2 consecutive days Total dose: 2.5 g chloroquine phosphate (1.5 g base) in 3 days Less than 60 kg: First dose: 16.7 mg chloroquine phosphate/kg (10 mg base/kg) orally Second dose (6 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Third dose (24 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Fourth dose (36 hours after first dose): 8.3 mg chloroquine phosphate/kg (5 mg base/kg) orally Total dose: 41.7 mg chloroquine phosphate/kg (25 mg base/kg) in 3 days Comments: -Concomitant therapy with an 8-aminoquinoline compound is necessary for radical cure of malaria due to P vivax and P malariae.

    Chloroquine cytokine

    Hydroxychloroquine DermNet NZ, Chloroquine Differentially Modulates Inflammatory Cytokine.

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  4. Because the lysosomotropic agent chloroquine has been effective in the treatment of diseases associated with increased secretion of proinflammatory cytokines such as malaria or rheumatoid arthritis, this study evaluates the potential effect of chloroquine on endotoxin-induced cytokinemia using human whole blood from healthy volunteers.

    • Chloroquine inhibits proinflammatory cytokine release into..
    • Chloroquine Differentially Modulates Inflammatory Cytokine Expression..
    • Chloroquine Dosage Guide with Precautions -.

    Chloroquine inhibits these cytokines, which helps to decrease inflammation. Uses Chloroquine is used for both the prevention and treatment of malaria. For those traveling to countries where malaria is an epidemic, it is recommended to take the drug 1-2 weeks before traveling until 4 weeks after leaving the destination. To study the effect of chloroquine on kinetics of cytokine mRNA expression, whole blood was stimulated with LPS in the absence or presence of 100 μM chloroquine for 0, 1, 2, 4, and 8 h. Chloroquine decreased TNF-α, IL-1β, and IL-6 mRNA expression after 1, 2, and 4 h, with a maximum inhibition after 4 h Fig.4. Fig. 4. Hopefully, clinical data with chloroquine will be published shortly. dosing Monograph from MedScape 500 mg chloroquine phosphate contains 300 mg of chlorquine itself a.k.a. chloroquine base. 500 mg PO twice daily for 10 days is the regimen recommended by a group in China for patients without contraindications.

     
  5. qawsed2004 Guest

    Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). Taking Plaquenil for Rheumatoid Arthritis Plaquenil Oral Uses, Side Effects, Interactions. How Does Plaquenil Work For Rheumatoid Arthritis
     
  6. Jayson Well-Known Member

    Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.

    Hydroxychloroquine - Wikipedia