While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Chloroquine diphospahe bbguy Tumors associated with plaquenil Plaquenil visual field Plaquenil and light sensitivity DÜSSELDORF, GERMANY — The anti-inflammatory compound hydroxychloroquine appears to be relatively safe during pregnancy, according to a small number of studies totaling about 250 patients. But these studies have not provided overwhelming evidence proving the safety of this agent in pregnancy, Jean-Charles Piette, M. D. said at an international conference on cutaneous lupus erythematosus. Chloroquine and mefloquine are the drugs of choice for pregnant women for destinations with chloroquine-sensitive and chloroquine-resistant malaria, respectively. Doxycycline is contraindicated because of teratogenic effects on the fetus after the fourth month of pregnancy. Summary. Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Is chloroquine safe during pregnancy Chloroquine - Wikipedia, Pregnant Travelers - Chapter 7 - 2020 Yellow Book. Plaquenil dosage autoimmune thyroiditisIs hydroxychloroquine safe to take during pregnancyHistory of chloroquine resistance Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2 Drug Safety in Pregnant & Nursing Women.. The Safety of Antimalarial Drugs in Pregnancy SpringerLink. Treatment of Malaria Guidelines For Clinicians United.. Chloroquine is the drug of choice for the prophylaxis and treatment of sensitive malaria species during pregnancy. Chloroquine should only be given during pregnancy when need has been clearly established. See references. Chloroquine Breastfeeding Warnings. Chloroquine is excreted into human milk. So the researchers say it is too soon to declare the drug safe for the small number of pregnant women who might need to take it. The cheapest and mostly widely used anti-malaria drug, called chloroquine, is considered safe during pregnancy. But resistance to that drug has become common worldwide. Sunday, 01 July 2018. In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. This is called her background risk. This sheet talks about whether exposure to hydroxychloroquine may increase the risk for birth defects over that background risk.