Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil cost for generic Plaquenil pregnancy sjogren's A sharp increase in the prevalence of retinal toxicity is noted following five to seven years of medication use. 6 Newer literature emphasizes the risk of cumulative dosing that occurs over a period of time 1,000g rather than the previous suggestion of 6.5mg/kg of body weight. Thus, annual screening is recommended after five years for non-high risk patients. I was diagnosed with PsA this time last year and have been on plaquenil 400 mg daily. thinking about the risk of retinal toxicity after 5 + years use stresses me out. I'm told it is rare but i feel that the more i dr google it the more incidences there are. id love to hear your experiences using the drug Retinal Damage. According to Drugs.com, Plaquenil given for a long term can cause retinal disorders after a few months or years of daily use--especially if the dose exceeds 400mg per day. The risk of retinal damage increases at doses of 600mg to 700mg. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Retinal toxicity from plaquenil years after discontinued Hydroxychloroquine toxicity - EyeWiki, Plaquenil long term use - i want to hear your success stories. Total synthesis of chloroquine An example of advanced toxicity is presented here. A 68-year-old female with rheumatoid arthritis was treated with hydroxychloroquine 200 mg PO bid for almost five years. She complained of bilateral visual disturbances and discontinued the medication. She reported progressive symptoms for over one year following discontinuation. New Screening Guidelines for Hydroxychloroquine Toxicity. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Sulfate Drug Information, Professional. Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11.