Chloroquine and receptor mediated endocytosis

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  1. Mirka XenForo Moderator

    Chloroquine and receptor mediated endocytosis


    Detailed information on how Wiley uses cookies can be found in our Privacy Policy. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it.

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    The third and the most specific mechanism of endocytosis is receptor-mediated endocytosis. During receptor-mediated endocytosis, receptors in the plasma membrane identify the macromolecules like cholesterol in the extracellular fluid. However, the main difference between endocytosis and phagocytosis is their correlation of the mechanisms. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious The RT-PCR, Western blot, and immunohistochemistry clearly suggested the expression of TCII receptor TCII-R in the inner and outer BRB. These results suggested the involvement of receptor-mediated endocytosis in the blood-to-retina transport of cyanocobalamin at the inner BRB with implying its possible involvement at the outer BRB. PMID 29966424

    It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.

    Chloroquine and receptor mediated endocytosis

    Inhibition of receptor-mediated uptake of a lysosomal., Chloroquine - Wikipedia

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  6. The key difference between endocytosis and receptor mediated endocytosis is that endocytosis is a cellular mechanism by which cells take in substances inside the cell by forming vesicles. Meanwhile, receptor-mediated endocytosis is a form of endocytosis in which receptors located on the cell surface are used to capture specific target molecules such as metabolites, hormones, proteins, etc.

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    Clathrin-mediated endocytosis CME, is also known as clathrin-dependent endocytosis CDE or receptor-mediated endocytosis. The pathway has been well studied in cell culture, yeast, and mammalian cells and shows a high degree of conservation 53, 58. Phagocytosis, pinocytosis and receptor-mediated endocytosis are the three methods of endocytosis, which is the process of taking materials into the cell by forming vesicles. Another name for pinocytosis is ‘ cell drinking ’ while receptor-mediated endocytosis is known as clathrin-mediated endocytosis as well. Receptor-mediated endocytosis RME, also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane invaginationprocess forms vesicles containing the absorbed substances and is strictly mediated by receptors on the surface of the cell.

     
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    A combination of leflunomide and hydroxychloroquine significantly reduced disease activity, increased salivary flow, and improved patient-perceived health in patients with primary Sjögren’s syndrome, a pilot trial showed. Conquering Sjogren's Plaquenil Sjogren's syndrome - Symptoms and causes - Mayo Clinic Medications for Sjogren’s Syndrome NYU Langone Health
     
  8. miffy XenForo Moderator

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