Pharmacological treatment with chloroquine inhibits autophagy in vivo

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  1. sleresmoove New Member

    Pharmacological treatment with chloroquine inhibits autophagy in vivo


    Several cancer treatments stimulate the autophagic process and when autophagy is inhibited, cancer cells show an enhanced response to multiple treatments. These findings have nourished the theory that autophagy provides cancer cells with a survival advantage during stressful conditions, including exposure to therapeutics.

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    Similarly, efficacy of mTOR inhibitor, everolimus, and tyrosine kinase inhibitor, gefitinib is enhanced with concurrent treatment of chloroquine compared with single drug administration. CQ derivatives such as Lys-01 and Lys-05 also display anti-tumor effects in adapted cells. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation. 1. Originally applied as an antimalarial medication, the use of chloroquine or chloroquine derivatives to inhibitor autophagy is currently being explored as possible chemotherapeutic interventions for the treatment of cancer. Here, we have explored the possible beneficial effect of combining antiestrogen therapies with hydroxychloroquine HCQ for the treatment of antiestrogen resistant ER+ breast cancers.

    In this review we examine two approaches to modulate autophagy as complementary cancer treatment: inhibition and induction. Therefore, interference with the autophagic response can potentially enhance the efficacy of cancer therapy.

    Pharmacological treatment with chloroquine inhibits autophagy in vivo

    Novel organometallic chloroquine derivative inhibits tumor., Chloroquine for research Cell-culture tested InvivoGen

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  6. The inhibition of hypoxia-induced autophagy by hydroxychloroquine promoted tumor regression in an in vivo subcutaneous B16 melanoma mouse model. Chloroquine treatment combined with calorie restriction inhibited melanoma tumor growth in a subcutaneous mouse model of B16 melanoma cells.

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    Aug 30, 2018 Clinical trials with chloroquine—a known autophagy inhibitor—were unable to achieve complete autophagy inhibition in vivo, warranting the search for more potent autophagy inhibitors. Nov 15, 2015 Indeed, preclinical studies have shown that the pharmacological inhibition of autophagy with agents including chloroquine, hydroxychloroquine, metformin, and desmethylclomipramine can enhance the cell-killing effect of cancer therapeutics, and a number of these agents are currently under investigation in clinical trials. However, many of these autophagy modulators are relatively nonspecific, and cytotoxicity in noncancerous tissues is still a concern. Importantly, co-injection with chloroquine CQ in vivo Fig. 1A–B, or co-treatment with baflomycin A 1 in vitro data not shown, both of which can block autophagy degradation in the lysosome, further elevated the punctuation, indicating that CBZ-induced autophagosomes were degraded in the lysosome 18, 30.

     
  7. Satan Claus Guest

    Patients often ask if their medications affect the risk of vision loss from age-related macular degeneration (AMD). Hydroxychloroquine Side Effects, Dosage, Uses, and More What Causes Age-Related Macular Degeneration? Hydroxychloroquine Retinopathy Still Alive and Well - The.
     
  8. Shaft Well-Known Member

    Plaquenil hydroxychloroquine sulfate Drug / Medicine. Rheumatoid arthritis is a form of arthritis with inflammation of the joints, characterised by stiffness, swelling and pain. Plaquenil may be used for short or long-term rheumatoid arthritis treatment.

    Hydroxychloroquine - Side Effects, Dosage, Interactions.