Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties. Plaquenil indication apl syndrome Hydroxychloroquine actavis Dry cough hydroxychloroquine Hydroxychloroquine sulphate bp 200mg Apr 18, 2016 Pancreatic ductal adenocarcinoma PDAC is among the deadliest cancers with a dismal 7% 5-year survival rate and is projected to become the second leading cause of cancer-related deaths by 2020. KRAS is mutated in 95% of PDACs and is a well-validated. The findings presented today focused on advanced pancreatic cancer patients who enrolled in XCELSIOR and were treated with a MEK inhibitor, trametinib, in combination with an autophagy inhibitor, hydroxychloroquine, a generic medication approved by the U. S. Food and Drug Administration FDA for treatment of malaria, as part of their clinical cancer care. Molecular Analysis for Therapy Choice MATCH Treatment Subprotocol H Phase II Study of Dabrafenib and Trametinib in Patients with tumors with BRAF V600E or V600K mutations excluding melanoma and thyroid cancer In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms). Trametinib hydroxychloroquine pancreatic cancer A randomised, double-blind, placebo-controlled trial of., Cancer Commons Using Real World Evidence to Show Initial. Plaquenil bone marrowPlaquenil capsuleLupus plaquenil prednisone Jan 31, 2019 Trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Trametinib and Hydroxychloroquine in Treating Patients With.. Clinical Trials for PatientPoint tablet - NMCC. Trametinib and Hydroxychloroquine in Treating Patients with.. A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. O'Hara et al. reported the results from a phase II, single arm study in patients with metastatic colon cancer treated with hydroxychloroquine in combination with standard first-line chemotherapy mFOLFOX6 29. Pancreatic Cancer is an online community for sharing information about innovative, science-based treatments for pancreatic cancer. Please note that this information is not intended to be a substitute for professional medical opinion, advice, or diagnosis. The combination of dabrafenib Tafinlar and trametinib Mekinist led to encouraging responses in patients with rare, incurable cancer of the digestive tract, according to phase II data presented.