Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Hydroxychloroquine dose for malaria Chloroquine mode of action Malaria parasites in the red blood cells are killed more rapidly by chloroquine or quinine than by proguanil, which is therefore not the best drug to use for the treatment of acute malaria. Soon after proguanil was introduced, it was observed that the drug was inactive as an inhibitor of the in vitro growth of p. Gallinaceum and p. Continue taking Chloroquine and Proguanil until four weeks after leaving the malaria area. Side effects As with most medications, side effects can occur in some patients. Possible side effects include rash, digestive problems, headache or an allergic reaction. Applies to proguanil oral tablet. Along with its needed effects, proguanil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur while taking proguanil Rare. Skin rash or itching Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Chloroquine and proguanil side effects Chloroquine - Wikipedia, Chloroquine and Proguanil - Superdrug Health Clinic Chloroquine posologieWhich is more effective methotrexate or plaquenilHydroxychloroquine burrelia burgdorferiChloroquine autophagy lc3 In all, 0.7% of travellers taking mefloquine had disabling neuropsychiatric adverse effects, compared with 0.09% of those taking proguanil plus chloroquine P = 0.021. Two travellers taking mefloquine 1 in 607 were admitted to hospital as a result of the adverse event, compared with 1 in 1181 travellers taking proguanil plus chloroquine. Comparison of adverse events associated with use of.. Proguanil Side Effects Common, Severe, Long Term -. Chloroquine Side Effects Common, Severe, Long Term -. For the Consumer. Cold, clammy skin. decreased urine. drowsiness. dry mouth. fast, weak pulse. increased thirst. lightheadedness, dizziness, or fainting. loss of appetite. muscle pain or cramps. numbness or tingling in the hands, feet, or lips. Chloroquine-proguanil recipients began receiving weekly doses with chloroquine ⩾1 week before travel and received daily doses with proguanil 1–2 days before travel. Chloroquine and proguanil were continued until 4 weeks after travel. Subjects recorded taking doses on diary cards, and compliance was assessed by review of returned drug. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, severe dizziness, trouble breathing. This is not a complete list of possible side effects.