Hydroxychloroquine (Plaquenil) is an anti-malarial medication used for a variety of inflammatory diseases including systemic lupus erythematosus as well as rheumatoid arthritis and Sjogren's Syndrome. Hydroxychloroquine is contraindicated for Marshall Protocol Plaquenil lingers in the system at least 50 days and cannot be taken while on the MP. Blaney reports he starts his patients on Benicar while they are waiting for Plaquenil to clear their system and has seen no adverse events. Hydroxychloroquin cardiac protective Retinal changes with the use of hydroxychloroquine Plaquenil like med Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower. Happily, going off plaquenil quelled the worst of my psoriasis, so the overall trade-off was eventually worth it for me. It wasn't very clear from your post whether it was the primary care doctor or the rheumatologist who wants him to decrease the plaquenil. It's ok to stop plaquenil without weaning, but I do recommend that if you feel you can wait til Monday, wait, and talk with your rheumy then. I felt that plaquenil wasn't helping, and was causing digestive problems for me, so with my dr. ok, I went off it. After two weeks off, I discovered it had been doing some good on the joint and muscle pain. I have been on the plaquenil 200 mgm for about 4 months now. He prefers to wait a couple months before starting minocycline. How to wean off plaquenil Prednisone and Plaquenil DailyStrength, Going off Plaquenil - Sclero Forums MAIN - Sclero Forums Saltwater fish chloroquine compatible with metroplexPlaquenil multiple sclerosisSynthesis of chloroquine slidesharePlaquenil aptt test Plaquenil isn a antiparasitic drug with anti-inflammatory affect. I have done a lot of research on this drug and haven't run into anybody who has complained of the withdrawal effect. Over the years on this site we have had quite a few people post that they didn't think that the plaquenil was working so they would stop taking it. Let me tell you what weaning down from Plaquenil is like.. Can you quit plaquenil cold turkey, or have to wean. Hydroxychloroquine Plaquenil. Nov 17, 2013 Methotrexate strong. You were weaned off Plaquenil hydroxychloroquine and started on methotrexate. Your therapy has been escalated. The Methotrexate is working and that is good. Your doctor will be involved with you for your connective tissue disorder for a long time. Hope this helps. Aug 26, 2016 Plaquenil damps down the reactiveness of the receptors that send out your “fighters”, which in us is overactive. Rather than strangling the life out of your immune system like steroid meds do, it attenuates the function to closer to normal. Over time it can slightly lower your white cell count. Hydroxychloroquine comes as a tablet to take by mouth. For prevention of malaria in adults, two tablets are usually taken once a week on exactly the same day of each week. The first dose is taken 1 to 2 weeks before traveling to an area where malaria is common, and then doses are continued for 8 weeks after exposure.