Chloroquine in cancer therapy a double edged sword of autophagy

Discussion in 'Pharmacy Northwest Canada' started by Denissimo, 23-Feb-2020.

  1. paulkh New Member

    Chloroquine in cancer therapy a double edged sword of autophagy


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    In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. 6 In other studies, treatment of various cancer cells with small-molecule autophagy inhibitors, such as 3-methyladenine. It is like a double-edged sword that can play either a protective or destructive role in cancer, by pro-survival. chloroquine, etc. are reported in pre-clinical and clinical study. in cancer therapy. Keywords Autophagy, cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of rapamycin inhibitors. According to current research, autophagy inhibition has been applied to a variety of cancer therapies, such as glioma, myeloma, breast cancer, rectal cancer, and prostate cancer. As a “double-edged sword” in cancer, the regulatory mechanism of autophagy in cancer is complicated, but the observations about specific molecular markers of.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Autophagy, a double-edged sword in anti-angiogenesis therapy., Targeting autophagy with small molecules for cancer therapy

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  4. Chloroquine in the Kidney, the Double-Edged Sword of Autophagy The use of chloroquine in combination with other chemotherapeutic reagents may enhance cancer treatment 8, 29, but normal cells also use autophagy to maintain homeostasis, and inhibition of autophagy by chloroquine may sensitize not only cancer cells, but also normal organs to chemotherapy.

    • Chloroquine in Cancer Therapy A Double-Edged Sword of..
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    Sep 01, 2009 The emerging role of autophagy in cancer is one of a double-edged sword Figure 1B. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation and probably some forms of therapy. Autophagy Blockade via Chloroquine CQ or Hydroxychloroquine HCQ Enhances the. Kimura, al.2013 Chloroquine in cancer therapy a double-edged sword of autophagy. Cancer Res.73, 3–7 6. Onorati, A. V. et al. 2018 Targeting autophagy in cancer. Cancer 124, 3307–3318 7. Lee, C. S. et al. 2019 MAP kinase and autophagy path-ways. There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers.

     
  5. oSpxFoxDp Guest

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine Uses, Dosage & Side Effects - Neck Pain Relief Tips for Rheumatoid Arthritis Pain Symptoms Healthboards - Immune & Autoimmune - Lupus SEVERE neck pain
     
  6. Petrucciani New Member

    Hi lupies (I know, we can't be defined by our disease(s) but it works here), I have noticed that quite a few of us take gabapentin (neurontin). My neurologist thought it may have been peripheral neuropathy and tried the Neurontin. I believe I've finally found the solution to my migraines. How to Treat Arthritis Pain With Neurontin or Gabapentin Healthfully Is Gabapentin Safe to Take? Does Gabapentin interact with Plaquenil, Salagen and Paxil?
     
  7. rrex Moderator

    Tremors - Lupus - MedHelp I have SLE, I am taking plaquenil, was on steroids 1 1/2 months, off now for 1 month. Usually around 4-5am, I start getting tremors. I get up at 6am for work. Most of the time I can do deep breathing exercises and they will go away but sometimes they last a little longer.

    Lupus Shaking Dr Garys Lupus Treatment System Cure.
     
  8. locma Moderator

    Plaquenil - FDA prescribing information, side effects and uses Jan 01, 2020 One Plaquenil tablet contains 200 mg of hydroxychloroquine sulfate, which is equivalent to 155 mg base. Take Plaquenil with a meal or a glass of milk. Malaria. Prophylaxis Adults 400 mg 310 mg base once weekly on the same day of each week starting 2 weeks prior to exposure, and continued for 4 weeks after leaving the endemic area.

    Plaquenil-Hydroxychloroquine sulfate 200mg Film-coated Tablets