Chloroquine treatment of amoebic liver abscess

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  1. Alekov New Member

    Chloroquine treatment of amoebic liver abscess


    After completion of treatment with tissue amebicides, administer luminal amebicides for eradication of the asymptomatic colonization state. Failure to use luminal agents can lead to relapse of infection in approximately 10% of patients.

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    Clinical experiences with the patient in this report confirm the effectiveness of therapy with emetine and chloroquine in the treatment of amebic liver abscesses. Needle aspiration of accessible abscesses is desirable. Negative titres exclude amoebic abscess as a diagnostic possibility. Diagnosis is 100% confirmed by aspiration of liver abscess, anchovy sauce is quiet diagnostic Sigmoidoscopy reveals characteristic amoebic ulcers Radiography often reveals elevation and fixation of right half of diaphragm Liver function tests and examination of stool for. Rarely, when patients of amoebic liver abscess are vomiting, injection chloroquine can be used in a dose of 0.3–0.6 G. base in 24 hours not exceeding 0.9 G. Chloroquine given alone is a safer drug than emetine in amoebic liver abscess, but unfortunately the relapse rate is almost 25%.

    The details on tissue and luminal amebicidal agents are discussed in Medication. In general, metronidazole, tinidazole, emetine, and dehydroemetine are active in invaded tissues; chloroquine is active only in the liver; tetracycline acts on the bowel wall; and diloxanide furoate, paromomycin, and iodoquinol are luminal agents only.

    Chloroquine treatment of amoebic liver abscess

    WHO Model Prescribing Information Drugs Used in Parasitic., Amoebic liver - SlideShare

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    • Chloroquine in the Treatment of Amoebic Liver Abscess - Europe PMC..
    • Amoebic liver abscess - Wikipedia.
    • Comparison of metronidazole and chloroquine for the..

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. Amebiasis. In treatment of amoebic liver abscess, chloroquine may be used instead of or in addition to other medications in the event of failure of improvement with metronidazole or another. The drug can also be used for the treatment of amoebic liver abscess and rheumatic disease. Others have said that the pill helped them not to contract malaria, however, caused some severe symtoms While emetine combined with emetine bismuth iodide is usually effective in the treatment of hepatic amoebiasis, there is a residue of cases of liver abscess in which these drugs fail to act. The author refers to the use of chloroquine in hepatic amoebiasis and suggests that it probably acts by concentration in the liver parenchyma for experimental observations on animals regarding relative.

     
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